Rabbit anti-Human DUSP13 Polyclonal Antibody | anti-DUSP13 antibody

DUSP13 (Dual Specificity Phosphatase 13, BEDP, Dual Specificity Phosphatase SKRP4, FLJ32450, MDSP, Testis-and Skeletal-muscle-specific DSP, TMDP)

Cat. Num. AAA611536

• Gene Names: DUSP13; BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13B; FLJ32450
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: DUSP13; Polyclonal Antibody; DUSP13 (Dual Specificity Phosphatase 13; BEDP; Dual Specificity Phosphatase SKRP4; FLJ32450; MDSP; Testis-and Skeletal-muscle-specific DSP; TMDP); Anti -DUSP13 (Dual Specificity Phosphatase 13; anti-DUSP13 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Species Crossreactivity: Chimpanzee, Human
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.

• Applicable Applications for anti-DUSP13 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-DUSP13 antibody

Principal Names: Dual specificity phosphatase 13 (DUSP13); BEDP; SKRP4; Testis-and-skeletal muscle-specific DSP; TMDP; MDSP; FLJ32450 Official Gene Symbol: DUSP13 Gen Bank Accession Number: NP_001007274 Gene ID: 51207 (Human) Gene Map Locus: 10q22.2 (Human) DUSP13, a novel DSP, is a member of highly conserved Protein-tyrosine phosphatase super family. Members of this family cooperate with protein kinases and play a vital role in cell cycle regulation. DUSP13 consists of a conserved catalytic domain and is expressed specifically in the testis and skeletal muscle. Based on mRNA localization and expression studies during development, DUSP13 is suggested to be expressed as 3 isoforms due to alternative splicing. Reports suggest DUSP13 might be involved in the regulation of meiosis and differentiation of testicular germ cells during spermatogenesis.

Product Categories/Family for anti-DUSP13 antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 56237018
• NCBI GeneID: 51207
• NCBI Accession #: NP_057448.3
• NCBI GenBank Nucleotide #: NM_016364.3
• UniProt Accession #: Q9UII6; Q5JSC6; Q6IAR0; Q96GC2; A8K776; A8K782; B3KPY1; B3KXT0; B4DUK0; Q6B8I1
• Molecular Weight: 22,149 Da
• NCBI Official Full Name: dual specificity protein phosphatase 13 isoform 6
• NCBI Official Synonym Full Names: dual specificity phosphatase 13
• NCBI Official Symbol: DUSP13
• NCBI Official Synonym Symbols: BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13B; FLJ32450
• NCBI Protein Information: dual specificity protein phosphatase 13; OTTHUMP00000019875; OTTHUMP00000233098; OTTHUMP00000239701; OTTHUMP00000239702; muscle-restricted DSP; branching-enzyme interacting DSP; dual specificity phosphatase SKRP4; dual-specificity phosphatase SKRP4; testis- and skeletal-muscle-specific DSP; dual specificity protein phosphatase 13 isoform MDSP; branching-enzyme interacting dual-specificity protein phosphatase
• UniProt Protein Name: Dual specificity protein phosphatase 13
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP13
• UniProt Synonym Gene Names: TMDP
• UniProt Entry Name: DUS13_HUMAN

NCBI Description

Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq]

Uniprot Description

DUSP13: May be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis. Exhibits intrinsic phosphatase activity towards both phospho- seryl/threonyl and -tyrosyl residues of myelin basic protein, with similar specific activities in vitro. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 5 isoforms of the human protein are produced by alternative promoter.

Protein type: EC 3.1.3.48; Protein phosphatase, dual-specificity; Cell cycle regulation; EC 3.1.3.16; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: cytoplasm

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: meiosis; spermatogenesis; protein amino acid dephosphorylation