Testing Data
Rabbit Profilin-1 Polyclonal Antibody | anti-Pfn1 antibody
Profilin-1 Antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
regulates actin polymerization; may reorganize the actin cytoskeleton; may be involved in the pathogenesis of glomerulonephritis [RGD, Feb 2006]
Uniprot Description
profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome.
Protein type: Cytoskeletal; Actin-binding; Motility/polarity/chemotaxis
Cellular Component: neuron projection; focal adhesion; cytoskeleton; membrane; cytoplasm; synapse; nucleus
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; Rho GTPase binding; adenyl-nucleotide exchange factor activity; actin binding; receptor binding
Biological Process: regulation of transcription from RNA polymerase II promoter; response to organic substance; positive regulation of DNA metabolic process; negative regulation of actin filament bundle formation; negative regulation of stress fiber formation; positive regulation of actin filament polymerization; positive regulation of viral transcription; positive regulation of ATPase activity; negative regulation of actin filament polymerization; actin polymerization and/or depolymerization; neural tube closure; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter
Research Articles on Pfn1
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Product Notes
The Pfn1 pfn1 (Catalog #AAA840785) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Profilin-1 Antibody reacts with Human, Mouse, Rat, Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's Profilin-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). The antibody can be used in Western Blot analysis (1-4 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. Expected band is ~15 kDa. Researchers should empirically determine the suitability of the Pfn1 pfn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Profilin-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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