Mouse Herpes Simplex Virus I, II, Glycoprotein D Monoclonal Antibody | anti-HS3ST3A1 antibody

Herpes Simplex Virus I, II, Glycoprotein D (HSV I, II, Herpes Simplex Virus 1, HSV1, Herpes Simplex Virus 2, HSV2)

Cat. Num. AAA609964

• Gene Names: HS3ST3A1; 30ST3A1; 3OST3A1
• Applications: ELISA, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Herpes Simplex Virus I; II; Glycoprotein D; Monoclonal Antibody; Glycoprotein D (HSV I; Herpes Simplex Virus 1; HSV1; Herpes Simplex Virus 2; HSV2); Anti -Herpes Simplex Virus I; anti-HS3ST3A1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 10D415
• Specificity: Recognizes glycoprotein D of Herpes Simplex Virus types 1 (HSV-1) and 2 (HSV-2).
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-HS3ST3A1 antibody: ELISA (EL/EIA), Immunofluorescence (IF)
• Application Notes: Suitable for use in ELISA and Immunofluorescence.
• Immunogen: Herpes Simplex Virus I, II, Glycoprotein D.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-HS3ST3A1 antibody

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two species of the herpes virus family, Herpesviridae, which cause infections in humans. They are also called Human Herpes Virus 1 and 2 (HHV-1 and HHV-2) and are neurotropic and neuroinvasive viruses; they enter and hide in the human nervous system, accounting for their durability in the human body. Under a microscope, HSV- 1 and 2 are virtually identical, sharing approximately 50% of their DNA. Both types infect the body's mucosal surfaces, usually the mouth or genitals, and then establish latency in the nervous system. HSV-1 is commonly associated with herpes outbreaks of the face known as cold sores or fever blisters, whereas HSV-2 is more often associated with genital herpes. Herpes simplex viruses (HSV) use multiple and sequential receptors to enter host cells. HSV glycoprotein D (gD) has been implicated in binding to cellular receptors that facilitate virus penetration into cells. Herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) is an essential component of the entry apparatus that is responsible for viral penetration and subsequent cell-cell spread.

Product Categories/Family for anti-HS3ST3A1 antibody

Antibodies; Abs to Infectious Disease Herpes

NCBI and Uniprot Product Information

• NCBI GI #: 61214551
• NCBI GeneID: 9955
• UniProt Accession #: Q9Y663; A8K7N2
• Molecular Weight: 44,900 Da
• NCBI Official Full Name: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
• NCBI Official Synonym Full Names: heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
• NCBI Official Symbol: HS3ST3A1
• NCBI Official Synonym Symbols: 30ST3A1; 3OST3A1
• NCBI Protein Information: heparan sulfate glucosamine 3-O-sulfotransferase 3A1; 3-OST-3A; h3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparin-glucosamine 3-O-sulfotransferase; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
• UniProt Protein Name: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
• Protein Family: Heparan sulfate glucosamine 3-O-sulfotransferase
• UniProt Gene Name: HS3ST3A1
• UniProt Synonym Gene Names: 3OST3A1; HS3ST3A; 3-OST-3A; Heparan sulfate 3-O-sulfotransferase 3A1; h3-OST-3A
• UniProt Entry Name: HS3SA_HUMAN

NCBI Description

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Jul 2008]

Uniprot Description

HS3ST3A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate. Belongs to the sulfotransferase 1 family.

Protein type: Membrane protein, integral; EC 2.8.2.23; Glycan Metabolism - glycosaminoglycan degradation; Glycan Metabolism - heparan sulfate biosynthesis; Transferase

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: sulfotransferase activity; [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

Biological Process: glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis