Structure
Luminespib, Inhibitor
Luminespib (AUY-922, NVP-AUY922)
Applications
Kinase Assay, Cell Assay
Purity
99.25%
Synonyms
Luminespib; Luminespib (AUY-922; NVP-AUY922); inhibitor
Purity/Purification
99.25%
Form/Format
POWDER
Applicable Applications for Luminespib, inhibitor
Kinase Assay, Cell Assay
Application Notes
Kinase Assay: NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.
Cell Assay: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50uL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference)
Cell line: Human gastric cancer cells NCI-N87
Cell Assay: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50uL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference)
Cell line: Human gastric cancer cells NCI-N87
CAS Number
747412-49-3
Molecular Formula
C26H31N3O5
Smiles
CCNC(=O)c1noc(c1-c1ccc(CN2CCOCC2)cc1)-c1cc(C(C)C)c(O)cc1O
Solubility
DMSO: 86 mg/mL (184.7 mM)
Ethanol: 29 mg/mL (62.3 mM)
Water: <1 mg/mL
(<1 mg/ml refers to the product slightly soluble or insoluble)
Ethanol: 29 mg/mL (62.3 mM)
Water: <1 mg/mL
(<1 mg/ml refers to the product slightly soluble or insoluble)
Receptor (IC50)
HSP90α - 13nM
HSP90β - 21nM
HSP90β - 21nM
Animal Experiment
Animal Model: FeNCr athymic mice bearing WM266.4 human melanoma xenografts
Preparation and Storage
2 years -80°C in solvent; 3 years -20°C powder;
Structure
Structure
Related Product Information for Luminespib, inhibitor
AUY922 (NVP-AUY922) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).
Similar Products
Product Notes
The Luminespib (Catalog #AAA575370) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Luminespib can be used in a range of immunoassay formats including, but not limited to, Kinase Assay, Cell Assay. Kinase Assay: NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep. Cell Assay: Human gastric cancer cells NCI-N87 (5-7 ×103 in 50uL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader. (Only for Reference) Cell line: Human gastric cancer cells NCI-N87. Researchers should empirically determine the suitability of the Luminespib for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Luminespib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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