Structure
Pemigatinib, Inhibitor
Pemigatinib
Purity
99.95%
Synonyms
Pemigatinib; INCB054828; inhibitor
Purity/Purification
99.95%
Form/Format
Solid. Powder
Solubility
DMSO: 40mg/mL (82.05mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H27F2N5O4
SMILES
CCN(C(N(C(C(F)=C(OC)C=C1OC)=C1F)C2)=O)C(C2=CN3)=C4C3=NC(CN5CCOCC5)=C4
CAS Number
1513857-77-6
Target & IC50
FGFR1: ic50 0.4nM
FGFR2: ic50 0.5nM
FGFR3: ic50 1.2nM
FGFR4: ic50 30nM
FGFR2: ic50 0.5nM
FGFR3: ic50 1.2nM
FGFR4: ic50 30nM
In Vitro
In cells expressing FGFR2-CLIP1 fusion are sensitive to Pemigatinib (INCB054828; IC50 value of 10.16nM)[3].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Pemigatinib, inhibitor
Pemigatinib is an orally active, selective inhibitor of FGFR(IC50s of 0.4nM, 0.5nM, 1.2nM, 30nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).
Product Categories/Family for Pemigatinib, inhibitor
References
Arudra K, et al. Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment,of Wilms tumor. J Cutan Pathol. 2018 Oct;45(10):786-790.
Arudra K, et al. Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment,of Wilms tumor. J Cutan Pathol. 2018 Oct;45(10):786-790.
Roskoski R Jr, et al. The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment,of cancers including those of the urinary bladder. Pharmacol Res. 2020 Jan;151:104567.
Roskoski R Jr, et al. The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment,of cancers including those of the urinary bladder. Pharmacol Res. 2020 Jan;151:104567.
Krook MA, et al. Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy. Cold Spring Harb Mol Case Stud. 2019 Aug 1;5(4).
Krook MA, et al. Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy. Cold Spring Harb Mol Case Stud. 2019 Aug 1;5(4).
Arudra K, et al. Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment,of Wilms tumor. J Cutan Pathol. 2018 Oct;45(10):786-790.
Roskoski R Jr, et al. The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment,of cancers including those of the urinary bladder. Pharmacol Res. 2020 Jan;151:104567.
Roskoski R Jr, et al. The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment,of cancers including those of the urinary bladder. Pharmacol Res. 2020 Jan;151:104567.
Krook MA, et al. Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy. Cold Spring Harb Mol Case Stud. 2019 Aug 1;5(4).
Krook MA, et al. Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy. Cold Spring Harb Mol Case Stud. 2019 Aug 1;5(4).
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Product Notes
The Pemigatinib (Catalog #AAA5753658) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Pemigatinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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