Structure
Nintedanib Ethanesulfonate Salt, Inhibitor
Nintedanib Ethanesulfonate Salt
Purity
98.00%
Synonyms
Nintedanib Ethanesulfonate Salt; BIBF 1120(esylate); Nintedanib esylate; Intedanib; BIBF 1120; inhibitor
Purity/Purification
98.00%
Form/Format
Powder
Formula
C31H33N5O4.C2H6O3S
CAS
656247-18-6
Smiles
CCS(O)(=O)=O.COC(=O)c1ccc2c(NC(=O)\C2=C(/Nc2ccc(cc2)N(C)C(=O)CN2CCN(C)CC2)c2ccccc2)c1
Receptor (IC50)
VEGFR1: 34nM
VEGFR2: 13nM, VEGFR3: 13nM
FGFR1: 69nM
FGFR2: 37nM
FGFR3: 108nM
PDGFRalpha: 59nM
PDGFRbeta: 65nM
VEGFR2: 13nM, VEGFR3: 13nM
FGFR1: 69nM
FGFR2: 37nM
FGFR3: 108nM
PDGFRalpha: 59nM
PDGFRbeta: 65nM
Solubility
DMSO: 92.85mg/mL (142.90mM), Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Structure
Related Product Information for Nintedanib Ethanesulfonate Salt, inhibitor
BIBF 1120 esylate is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRalpha/beta
Product Categories/Family for Nintedanib Ethanesulfonate Salt, inhibitor
References
1. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52 (14), 4466-4480.
2. Suzuki N, et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36 (6):3123-3130.
2. Suzuki N, et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36 (6):3123-3130.
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Product Notes
The Nintedanib Ethanesulfonate Salt (Catalog #AAA5751476) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Nintedanib Ethanesulfonate Salt, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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