Chemical Structure
FGFR1/DDR2 1, Inhibitor | FGFR1/DDR21, inhibitor
FGFR1/DDR2 inhibitor 1
Purity
0.9914
Synonyms
FGFR1/DDR2 1; FGFR1/DDR2 inhibitor 1; FGFR1/DDR21; inhibitor
Purity/Purification
0.9914
Form/Format
Solid
Solubility
H2O: < 0.1mg/mL (insoluble)
DMSO: 250mg/mL (498.50mM)
Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
DMSO: 250mg/mL (498.50mM)
Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CC4=C(C=C3)C(=NN4)C5=CN(N=C5)C6CC6
Formula
C28H22F3N5O
Target & IC50
FGFR1, KG-1, DDR2
CAS Number
2308497-58-5
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for FGFR1/DDR21, inhibitor
FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1,108.4 and 3.2 for FGFR1,KG-1,and DDR2,respectively.
Product Categories/Family for FGFR1/DDR21, inhibitor
References
Wang Q, et al. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma. Eur J Med Chem. 2019 Feb 1;163:671-689.
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Product Notes
The FGFR1/DDR21 (Catalog #AAA5764597) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FGFR1/DDR2 1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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