Erythropoietin-alpha Recombinant Protein | EPO recombinant protein
Human Erythropoietin-alpha Recombinant
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Recombinant EPO-a is a glycosylated disulfide-linked homodimeric protein consisting of 166 amino acid residue subunits, and migrates as an approximately 35 kDa protein under reducing conditions in SDS-PAGE.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
• erk- and akt-dependent neuroprotection by erythropoietin (EPO) against glyoxal-ages via modulation of bcl-xl, bax and bad .Invest. Ophthalmol. Vis. Sci., Jul 2009; 10.1167/iovs.09-3544.
• the characteristics of technical character and the ongoing saga in the EPO and the english courts .Journal of Intellectual Property Law Practice, Jul 2009; 4: 506 - 514.
• comparison of EPOetin alfa (EPO) and darbEPOetin alfa (darb) utilization in cancer chemotherapy patients treated in a hospital outpatient setting .ASCO Meeting Abstracts, May 2009; 27: e17524.
• phase ii study of sagopilone (zk-EPO) in patients with recurrent metastatic breast cancer (mbc) .ASCO Meeting Abstracts, May 2009; 27: 1083.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]
Uniprot Description
EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: extracellular space; cell surface; extracellular region
Molecular Function: protein binding; erythropoietin receptor binding; hormone activity; protein kinase activator activity
Biological Process: hemoglobin biosynthetic process; erythrocyte maturation; blood circulation; apoptosis; positive regulation of transcription, DNA-dependent; response to lipopolysaccharide; response to testosterone stimulus; signal transduction; response to salt stress; response to vitamin A; peptidyl-serine phosphorylation; response to hyperoxia; positive regulation of tyrosine phosphorylation of Stat5 protein; response to estrogen stimulus; positive regulation of protein kinase activity; positive regulation of cell proliferation; positive regulation of Ras protein signal transduction; response to axon injury; response to electrical stimulus; positive regulation of neuron differentiation; positive regulation of DNA replication; embryo implantation; aging
Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2
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Product Notes
The EPO epo (Catalog #AAA553224) is a Recombinant Protein produced from Chinese Hamster Ovary Cells (CHO) and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGVHECPAWL WLLLSLLSLP LGLPVLGAPP RLICDSRVLE RYLLEAKEAE NITTGCAEHC SLNENITVPD TKVNFYAWKR MEVGQQAVEV WQGLALLSEA VLRGQALLVN SSQPWEPLQL HVDKAVSGLR SLTTLLRALG AQKEAISPPD AASAAPLRTI TADTFRKLFR VYSNFLRGKL KLYTGEACRT GDR. It is sometimes possible for the material contained within the vial of "Erythropoietin-alpha, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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