Mouse anti-Human CD2 Monoclonal Antibody | anti-CD2 antibody

CD2

Cat. Num. AAA370122

• Reactivity: Human
• Synonyms: CD2; Monoclonal Antibody; anti-CD2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1/K
• Clone Number: AB75
• Form/Format: CD2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

• Control: Tonsil
• Localization: Membranous
• Reactivity Note: Paraffin, Frozen
• Preparation and Storage: Store at 2 to 8 degree C in the dark.

Dilution Information

Immunohistochemistry (IHC)

Related Product Information for anti-CD2 antibody

CD2 is a cell-adhesion molecule found on the surface of T-cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion. It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T-cells. It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B-lymphocytes. CD2 is implicated in the triggering of T-cells; the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of Lymphomas and Leukemias of T-cell origin. As with other pan-T cell antigens, CD2 may be aberrantly deleted in some neoplastic T-cell populations, especially Peripheral T-cell Lymphomas.

NCBI and Uniprot Product Information

• NCBI GI #: 306518584
• NCBI GeneID: 677855
• NCBI Accession #: NP_001182402.1
• NCBI GenBank Nucleotide #: NM_001195473.1
• NCBI Official Full Name: CD2 molecule
• NCBI Official Symbol: CD2
• NCBI Protein Information: CD2 molecule; cluster of differentiation 2
• Protein Family: CD2