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Dilution Information

Mouse anti-Human CD38 Monoclonal Antibody | anti-CD38 antibody

CD38

Gene Names
CD38; T10
Reactivity
Human
Synonyms
CD38; Monoclonal Antibody; anti-CD38 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
SPC32
Form/Format
CD38 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Tonsil, Lymph Node
Localization
Membranous
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.

Dilution Information

Dilution Information

Immunohistochemistry (IHC)

Immunohistochemistry (IHC)
Related Product Information for anti-CD38 antibody
CD38 is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It is a marker of cell activation. The CD38 protein has been connected to HIV infection, Leukemias, Myelomas, solid tumors, Type II Diabetes Mellitus and bone metabolism, as well as some genetically-determined conditions. It has also been used as a prognostic marker in Leukemia. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages, and may be detected on cells from Multiple Myeloma, ALL (B and T) and some AML. Monoclonal antibodies to CD38 have been shown to be useful in subtyping of Lymphomas and Leukemias, inhibition of B-lymphopoiesis, detection of plasma cells, protection of B-cells from apoptosis, and as a marker for activated B and T-cell proliferation.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
952
UniProt Accession #
Molecular Weight
34,328 Da
NCBI Official Full Name
CD38
NCBI Official Synonym Full Names
CD38 molecule
NCBI Official Symbol
CD38
NCBI Official Synonym Symbols
T10
NCBI Protein Information
ADP-ribosyl cyclase 1; cADPr hydrolase 1; CD38 antigen (p45); OTTHUMP00000158633; OTTHUMP00000217743; NAD(+) nucleosidase; cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Protein Name
ADP-ribosyl cyclase 1
UniProt Gene Name
CD38
UniProt Entry Name
CD38_HUMAN

NCBI Description

CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq]

Uniprot Description

Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Catalytic activity: NAD+ + H2O = ADP-ribose + nicotinamide.

Enzyme regulation: ATP inhibits the hydrolyzing activity.

Subcellular location: Membrane; Single-pass type II membrane protein.

Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. Ref.2

Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

Sequence similarities: Belongs to the ADP-ribosyl cyclase family.

Research Articles on CD38

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Product Notes

The CD38 cd38 (Catalog #AAA370128) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD38 reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CD38, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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