NTCP binder peptide WL4, Inhibitor
NTCP binder peptide WL4
Purity
>98% (HPLC)
Synonyms
NTCP binder peptide WL4; inhibitor
Purity/Purification
>98% (HPLC)
Target
HBV
Receptor
HBV
Chemical Name
Cyclo-S-Ac-Tyr-Phe-Ile-Ile-ValMe-Gly-Thr-Trp-Thr-Trp-Thr-Trp-Ser-Cys-Thr-NH2
Molecular Formula
C99H122N20O20S
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for NTCP binder peptide WL4, inhibitor
NTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=42nM), reduces HBs antigen levels in culture supernatants with IC50 of 0.66uM; also inhibits cellular entry by the related hepatitis D virus (HDV), and is active against diverse strains of HBV (including clinically relevant nucleos (t)ide analog-resistant and vaccine escaping strains); exhibitsno inhibition of NTCP-mediated bile acid uptake in contrast to other NTCP-binding HBV entry inhibitors.
Product Categories/Family for NTCP binder peptide WL4, inhibitor
References
1. Passioura T, et al. Cell Chem Biol. 2018 Jul 19; 25 (7):906-915.e5.
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Product Notes
The NTCP binder peptide WL4 (Catalog #AAA3607077) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NTCP binder peptide WL4, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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