Structure
PC945, Inhibitor
PC945
Purity
>98% (HPLC)
Synonyms
PC945; PC 945; inhibitor
Purity/Purification
>98% (HPLC)
Target
Fungal
Receptor
Fungal
Chemical Name
4-[4-(4-{[(3R, 5R)-5-(2, 4-difluorophenyl)-5-(1H-1, 2, 4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}-3-methylphenyl)piperazin-1-yl]-N-(4-fluorophenyl)benzamide
Molecular Formula
C38H37F3N6O3
CAS Number
1931946-73-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PC945, inhibitor
PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14alpha-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22uM, respectively; shows MIC values 0.032 to >8ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034ug/ml; PC945 is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2ug/ml, and exhibits activity in vivo.Fungal Infection Phase 1 Clinical
Product Categories/Family for PC945, inhibitor
References
1. Colley T, et al. Antimicrob Agents Chemother. 2017 Apr 24; 61 (5). pii: e02280-16.
2. Kimura G, et al. Antimicrob Agents Chemother. 2017 Aug 24; 61 (9). pii: e00124-17.
2. Kimura G, et al. Antimicrob Agents Chemother. 2017 Aug 24; 61 (9). pii: e00124-17.
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Product Notes
The PC945 (Catalog #AAA3603027) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PC945, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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