Structure
GLS4, Inhibitor
GLS4
Purity
>98% (HPLC)
Synonyms
GLS4; GLS 4; Morphothiadin; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 100mg/mL (196.31mM)
H2O: <0.1mg/mL
H2O: <0.1mg/mL
Target
HBV
Receptor
HBV
Chemical Name
ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1, 4-dihydropyrimidine-5-carboxylate
SMILES
CCOC(=O)C1=C(NC(=NC1C2=C(C=C(C=C2)F)Br)C3=NC=CS3)CN4CCOCC4
Molecular Formula
C21H22BrFN4O3S
CAS Number
1092970-12-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GLS4, inhibitor
GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24nM) and reduces HBV-DNA levels in HepG.2.2.15 cells (IC50=14nM), shows efficacy against ADV-resistant HBV mutations; strongly inhibits core gene expression (at 100 to 200nM), suppresses virus accumulation in the supernantant of HepAD38 cells; inhibits HBV replicative forms in the live, shows strong and sustained suppression of virus DNA in treated mice. HBV Infection Phase 3 Clinical
Product Categories/Family for GLS4, inhibitor
References
1. Wang XY, et al. Antivir Ther. 2012; 17 (5):793-803.
2. Wu G, et al. Antimicrob Agents Chemother. 2013 Nov; 57 (11):5344-54.
3. Ren Q, et al. Bioorg Med Chem. 2017 Feb 1; 25 (3):1042-1056.
4. Tu T, et al. J Virol. 2018 Feb 7. pii: JVI.02007-17.
2. Wu G, et al. Antimicrob Agents Chemother. 2013 Nov; 57 (11):5344-54.
3. Ren Q, et al. Bioorg Med Chem. 2017 Feb 1; 25 (3):1042-1056.
4. Tu T, et al. J Virol. 2018 Feb 7. pii: JVI.02007-17.
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Product Notes
The GLS4 (Catalog #AAA3600356) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GLS4, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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