Structure
NVP-BEP800, Inhibitor
NVP-BEP800
Purity
>98% (HPLC)
Synonyms
NVP-BEP800; VER-82576; VER82576; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 6.2mg/mL (Need ultrasonic)
Target
HSP
Receptor
HSP90beta
Chemical Name
Thieno[2, 3-d]pyrimidine-6-carboxamide, 2-amino-4-[2, 4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethyl
SMILES
O=C(C1=CC2=C(C3=CC(OCCN4CCCC4)=C(Cl)C=C3Cl)N=C(N)N=C2S1)NCC
Molecular Formula
C21H23Cl2N5O2S
CAS Number
847559-80-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NVP-BEP800, inhibitor
A potent and selective Hsp90beta inhibitor with IC50 of 58nM; shows >70-fold selective against Grp94 and Trap-1; induces ErbB2, B-Raf (V600E), Raf-1, Akt and Hsp70 induction in A375 melanoma and BT-474 breast cancer cell lines; orally bioactive. Breast Cancer Preclinical
Product Categories/Family for NVP-BEP800, inhibitor
References
1. Massey AJ, et al. Mol Cancer Ther. 2010 Apr; 9 (4):906-19.
2. Brough PA, et al. J Med Chem. 2009 Aug 13; 52 (15):4794-809.
3. Stingl L, et al. Br J Cancer. 2010 May 25; 102 (11):1578-91.
2. Brough PA, et al. J Med Chem. 2009 Aug 13; 52 (15):4794-809.
3. Stingl L, et al. Br J Cancer. 2010 May 25; 102 (11):1578-91.
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Product Notes
The NVP-BEP800 (Catalog #AAA3606149) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NVP-BEP800, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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