Structure
OSU-03012 Biochemical
OSU-03012
Purity
>98% (HPLC)
Synonyms
OSU-03012; AR-12; AR 12; OSU 03012; OSU-03012 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 9mg/mL (19.5mM)
Ethanol: <1mg/mL
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Ethanol: <1mg/mL
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
PDK
Receptor
PDK1
Chemical Name
2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide
SMILES
NCC(=O)NC1=CC=C(C=C1)N1N=C(C=C1C1=CC2=C(C=C1)C1=CC=CC=C1C=C2)C(F)(F)F
Molecular Formula
C26H19F3N4O
CAS Number
742112-33-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for OSU-03012 biochemical
OSU-03012 (AR-12) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 5uM; induces apoptosis in PC-3 cells at low microM range, causes Akt dephosphorylation and inhibition of p70 S6 kinase activity; displays cytotocixity against a panel of 60 cell lines with mean GI50 of 3uM; decreases incidences of carcinoma and metastasis in transgenic mouse model of prostate cancer. Blood Cancer Phase 1 Clinical
Product Categories/Family for OSU-03012 biochemical
References
1. Johnson AJ, et al. Blood. 2005 Mar 15; 105 (6):2504-9.
2. Tseng PH, et al. Blood. 2005 May 15; 105 (10):4021-7.
3. Zhu J, et al. Cancer Res. 2004 Jun 15; 64 (12):4309-18.
4. Baryawno N, et al. Cancer Res. 2010 Jan 1; 70 (1):266-76.
2. Tseng PH, et al. Blood. 2005 May 15; 105 (10):4021-7.
3. Zhu J, et al. Cancer Res. 2004 Jun 15; 64 (12):4309-18.
4. Baryawno N, et al. Cancer Res. 2010 Jan 1; 70 (1):266-76.
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Product Notes
The OSU-03012 (Catalog #AAA3605832) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "OSU-03012, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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