Structure
SF2523, Inhibitor
SF2523
Purity
>98% (HPLC)
Synonyms
SF2523; SF-2523; SF 2523; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=30mg/mL
Target
PI3K
Receptor
BRD4; DNA-PK; mTOR; PI3Kalpha; PI3Kgamma
Chemical Name
7H-Thieno[3, 2-b]pyran-7-one, 3-(2, 3-dihydro-1, 4-benzodioxin-6-yl)-5-(4-morpholinyl)
SMILES
O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC=C(OCCO5)C5=C4
Molecular Formula
C19H17NO5S
CAS Number
1174428-47-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SF2523, inhibitor
A novel potent, dual inhibitor of PI3K and BRD4 with IC50 of 241, 34, 158nM for BRD4 (BD1), PI3Kalpha and PI3Kgamma, respectively; interacts robustly with the full-length BRD4 (Kd=140nM) and BRD4 (BD1) (Kd=150nM), binds more weakly BRD4 (BD2) (Kd=710nM); blocks MYC expression and activation, promotes MYC degradation, and markedly inhibits cancer cell growth and metastasis both in vitro and in vivo.
Product Categories/Family for SF2523, inhibitor
References
1. Andrews FH, et al. Proc Natl Acad Sci U S A. 2017 Feb 14; 114 (7):E1072-E1080.
2. Carlino L, et al. J Med Chem. 2016 Oct 27; 59 (20):9305-9320.
3. Shen G, et al. Biochem Biophys Res Commun. 2017 Nov 10. pii: S0006-291X (17)32240-4.
2. Carlino L, et al. J Med Chem. 2016 Oct 27; 59 (20):9305-9320.
3. Shen G, et al. Biochem Biophys Res Commun. 2017 Nov 10. pii: S0006-291X (17)32240-4.
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Product Notes
The SF2523 (Catalog #AAA3600593) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SF2523, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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