Immunohistochemistry (IHC)
(Sample Type :Human placental tissue Primary Antibody Dilution :1:50Secondary Antibody :Goat anti rabbit-HRP Secondary Antibody Dilution :1:10,000Color/Signal Descriptions :Brown: CAV2Purple: HaemotoxylinGene Name :CAV2Submitted by :Dr. Hiten D. Mistry and Anna Czajka, King's College London; Lesia Kurlak, University of Nottingham )
Rabbit CAV2 Polyclonal Antibody | anti-CAV2 antibody
CAV2 antibody - N-terminal region
Immunohistochemistry (IHC)
(Sample Type :Human placental tissue Primary Antibody Dilution :1:50Secondary Antibody :Goat anti rabbit-HRP Secondary Antibody Dilution :1:10,000Color/Signal Descriptions :Brown: CAV2Purple: HaemotoxylinGene Name :CAV2Submitted by :Dr. Hiten D. Mistry and Anna Czajka, King's College London; Lesia Kurlak, University of Nottingham )
Immunohistochemistry (IHC)
(Sample Type :Human placental tissue Primary Antibody Dilution :1:50Secondary Antibody :Goat anti rabbit-HRP Secondary Antibody Dilution :1:10,000Color/Signal Descriptions :Brown: CAV2Purple: HaemotoxylinGene Name :CAV2Submitted by :Dr. Hiten D. Mistry and Anna Czajka, King's College London; Lesia Kurlak, University of Nottingham )
Western Blot (WB)
(Lanes:Lane1: 50 ug human placental tissue lysateLane2: 40 ug human placental tissue lysateLane3: 30 ug human placental tissue lysateLane4: 20 ug human placental tissue lysateLane5: 20 ug human myometrial tissue lysatePrimary Antibody Dilution:1:500Secondary Antibody:Goat anti-rabbit HRPSecondary Antibody Dilution:1:10000Gene Name:Caveolin 2Submitted by:Hiten Mistry, Ania Czajka and Marta Hentschke Ribeiro, King's College London)
Western Blot (WB)
(Lanes:Lane1: 50 ug human placental tissue lysateLane2: 40 ug human placental tissue lysateLane3: 30 ug human placental tissue lysateLane4: 20 ug human placental tissue lysateLane5: 20 ug human myometrial tissue lysatePrimary Antibody Dilution:1:500Secondary Antibody:Goat anti-rabbit HRPSecondary Antibody Dilution:1:10000Gene Name:Caveolin 2Submitted by:Hiten Mistry, Ania Czajka and Marta Hentschke Ribeiro, King's College London)
Western Blot (WB)
(WB Suggested Anti-CAV2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human Lung)
Western Blot (WB)
(WB Suggested Anti-CAV2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human Lung)
Target Description: CAV2 is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
Uniprot Description
Caveolin-2: a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q31.1
Cellular Component: Golgi apparatus; focal adhesion; protein complex; integral to plasma membrane; caveola; acrosomal membrane; lipid raft; Golgi membrane; transport vesicle; extrinsic to internal side of plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; cytoplasmic vesicle; intracellular; nucleus
Molecular Function: protein binding; protein homodimerization activity; D1 dopamine receptor binding
Biological Process: endoplasmic reticulum organization and biogenesis; positive regulation of dopamine receptor signaling pathway; mitochondrion organization and biogenesis; vesicle organization and biogenesis; skeletal muscle fiber development; protein oligomerization; vesicle fusion; vesicle docking; positive regulation of MAPKKK cascade; negative regulation of endothelial cell proliferation; insulin receptor signaling pathway; regulation of mitosis; positive regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of GTPase activity
Research Articles on CAV2
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Product Notes
The CAV2 cav2 (Catalog #AAA3224441) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CAV2 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's CAV2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the CAV2 cav2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: LVIPYNEKPE KPAKTQKTSL DEALQWRDSL DKLLQNNYGL ASFKSFLKSE. It is sometimes possible for the material contained within the vial of "CAV2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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