NCBI and Uniprot Product Information
Uniprot Description
PELI1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Found in a complex containing TRAF6, IRAK1 and IRAK4. Interacts with MAP3K7. Belongs to the pellino family.
Protein type: Ligase; Ubiquitin ligase; Ubiquitin conjugating system; Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: cytosol
Molecular Function: protein binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade
Research Articles on PELI1
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Product Notes
The PELI1 peli1 (Catalog #AAA1273708) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTTTTCTC CTGATCAAGA AAATCATCCA TCTAAAGCAC CAGTAAAATA TGGTGAACTC ATTGTCTTAG GGTATAATGG GTCTCTCCCA AATGGCGATA GAGGAAGGAG GAAAAGTAGG TTTGCTTTGT TTAAAAGACC TAAGGCAAAT GGGGTGAAGC CCAGCACTGT GCATATTGCT TGTACTCCTC AGGCTGCAAA GGCAATAAGC AACAAAGACC AGCATAGCAT ATCATATACT TTATCTCGGG CCCAGACTGT GGTGGTTGAA TATACTCATG ACAGCAACAC CGATATGTTT CAGATTGGCC GGTCGACTGA AAGCCCCATT GATTTTGTAG TAACTGACAC GGTTCCTGGA AGTCAAAGTA ATTCTGATAC ACAGTCAGTA CAAAGCACTA TATCAAGATT TGCCTGCAGA ATCATATGTG AACGGAATCC TCCCTTTACA GCACGGATTT ATGCTGCAGG ATTTGACTCA TCAAAAAACA TCTTTCTTGG GGAGAAGGCT GCCAAATGGA AGACATCAGA TGGACAGATG GATGGCTTGA CCACTAATGG TGTTCTTGTG ATGCATCCAC GCAATGGGTT CACAGAAGAC TCCAAGCCTG GAATATGGAG AGAAATATCG GTGTGTGGAA ATGTATTTAG CCTACGTGAA ACCAGATCGG CTCAGCAGAG AGGAAAAATG GTGGAAATTG AAACCAATCA GTTACAAGAT GGCTCGTTAA TTGACCTCTG TGGTGCAACA TTGTTATGGC GTACTGCAGA AGGCCTTTCC CACACTCCTA CCGTGAAGCA TTTAGAAGCT TTAAGACAGG AAATCAATGC AGCACGACCT CAGTGCCCTG TAGGGTTCAA CACACTAGCA TTTCCTAGTA TGAAGAGGAA AGACGTTGTA GATGAAAAAC AACCATGGGT ATATCTAAAC TGCGGCCATG TACATGGCTA TCATAACTGG GGAAACAAAG AAGAACGTGA TGGAAAAGAT CGTGAATGTC CTATGTGTAG GTCTGTTGGT CCCTATGTTC CTCTGTGGCT TGGATGTGAA GCTGGATTTT ATGTGGACGC CGGCCCTCCA ACCCATGCGT TTAGCCCGTG TGGGCATGTG TGTTCAGAAA AGACAACTGC CTATTGGTCC CAGATCCCAC TTCCTCATGG TACTCATACT TTTCATGCAG CCTGTCCCTT TTGTGCACAT CAGTTGGCTG GTGAACAAGG CTACATCAGA CTTATTTTTC AAGGACCTCT AGACTAA. It is sometimes possible for the material contained within the vial of "PELI1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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