Immunohistochemistry (IHC)
(Primary Metastatic Melenoma SpecimanPrimary antibody dilution: 1:1000)
Rabbit POU3F2 Polyclonal Antibody | anti-POU3F2 antibody
POU3F2 antibody - middle region
Immunohistochemistry (IHC)
(Primary Metastatic Melenoma SpecimanPrimary antibody dilution: 1:1000)
Immunohistochemistry (IHC)
(Primary Metastatic Melenoma SpecimanPrimary antibody dilution: 1:1000)
Immunohistochemistry (IHC)
(Sample Type :Mouse adult cortexPrimary Antibody Dilution :1:1000Secondary Antibody :Donkey anti rabbit IgG Alexa 594Secondary Antibody Dilution :1:1000Gene Name :POU3F2 Submitted by :Dr. Jin Hee Lee, Ph.D., Winthrop-University Hospital)
Immunohistochemistry (IHC)
(Sample Type :Mouse adult cortexPrimary Antibody Dilution :1:1000Secondary Antibody :Donkey anti rabbit IgG Alexa 594Secondary Antibody Dilution :1:1000Gene Name :POU3F2 Submitted by :Dr. Jin Hee Lee, Ph.D., Winthrop-University Hospital)
Western Blot (WB)
(WB Suggested Anti-POU3F2 Antibody Titration: 0.5ug/mlELISA Titer: 1:12500Positive Control: Jurkat cell lysate)
Western Blot (WB)
(WB Suggested Anti-POU3F2 Antibody Titration: 0.5ug/mlELISA Titer: 1:12500Positive Control: Jurkat cell lysate)
Target Description: N-Oct-3 (POU3F2) is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1) and Oct2 (POU2F2), and the pituitary protein Pit1 (PIT1). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM].
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
Uniprot Description
Oct7: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters. Interacts with PQBP1. Expressed specifically in the neuroectodermal cell lineage. Belongs to the POU transcription factor family. Class- 3 subfamily. 3 isoforms of the human protein are produced by alternative initiation.
Protein type: Transcription factor; Motility/polarity/chemotaxis; DNA-binding
Chromosomal Location of Human Ortholog: 6q16
Cellular Component: transcription factor complex; nucleus
Molecular Function: identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: epidermis development; transcription, DNA-dependent; positive regulation of multicellular organism growth; hypothalamus cell differentiation; regulation of axonogenesis; astrocyte development; myelination in the peripheral nervous system; neuron differentiation; neurohypophysis development; positive regulation of cell proliferation; cerebral cortex radially oriented cell migration; positive regulation of transcription from RNA polymerase II promoter; forebrain ventricular zone progenitor cell division
Research Articles on POU3F2
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Product Notes
The POU3F2 pou3f2 (Catalog #AAA3200364) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The POU3F2 antibody - middle region reacts with Cow, Dog, Guinea Pig, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's POU3F2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the POU3F2 pou3f2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: LGAGGQPAGL HHHGLRDAHD EPHHADHHPH PHSHPHQQPP PPPPPQGPPG. It is sometimes possible for the material contained within the vial of "POU3F2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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