Testing Data
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Protein Z Protein
Protein Z
Purity
Purified~98% SDS-PAGE. Human protein Z is prepared from fresh frozen plasma similar to the procedure described by Broze and Miletich.
Synonyms
Protein Z; Protein Z protein
Purity/Purification
Purified
~98% SDS-PAGE. Human protein Z is prepared from fresh frozen plasma similar to the procedure described by Broze and Miletich.
~98% SDS-PAGE. Human protein Z is prepared from fresh frozen plasma similar to the procedure described by Broze and Miletich.
Extinction Coefficient
E 1 % 1 c m, 280 nm = 12.0
Mode of Action
Required for the binding of thrombin to phospholipid surfaces and for PZ dependent inhibition of factor Xa.
Structure
Single chain, (Mr=62,000), displays structural similarity to other vitamin K-dependent coagulation factors based on sequence homology, most notably factor X
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Testing Data
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Testing Data
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Related Product Information for Protein Z protein
Human protein Z (PZ) is a single chain, vitamin K-dependent plasma protein. Analogous with the majority of the coagulation proteins, protein Z is synthesized in the liver. The mature protein contains 360 amino acids. Based on amino acid sequence homology the domain structure is similar to that of other vitamin K-dependent zymogens which include factor VII, factor IX, factor X, and protein C. The N-terminal region contains a carboxyglutamic acid (Gla) domain important in its phospholipid membrane binding ability. Following the N-terminal Gla domain are two EGF domains and a region which connects to a catalytic-like domain. The C-terminal region has been shown to lack the "typical" serine protease activation site as well as the His and Ser residues from the catalytic triad. Protease activity has not been detected in either the full-length protein or cleavage products of protein Z. Functionally protein Z has been shown to be a direct requirement for the binding of thrombin to endothelial phospholipids. Protein Z also serves as a cofactor for the inhibition of coagulation factor Xa by a plasma serpin called protein Z-dependent protease inhibitor (ZPI). Inhibition is dependent upon complex formation between factor Xa-PZ-ZPI on the phospholipid surface.
Product Categories/Family for Protein Z protein
Similar Products
Product Notes
The Protein Z (Catalog #AAA635203) is a Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Protein Z, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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