Leukocyte-associated Immunoglobulin-like Receptor 2/LAIR2/CD306 Biotinylated Recombinant Protein | LAIR2/CD306 recombinant protein

Recombinant Human Leukocyte-associated Immunoglobulin-like Receptor 2/LAIR2/CD306 (C-Avi-6His) Biotinylated

Cat. Num. AAA2569147

• Gene Names: LAIR2; CD306
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Leukocyte-associated Immunoglobulin-like Receptor 2/LAIR2/CD306 Biotinylated; Recombinant Human Leukocyte-associated Immunoglobulin-like Receptor 2/LAIR2/CD306 (C-Avi-6His) Biotinylated; Leukocyte-Associated Immunoglobulin-Like Receptor 2; LAIR-2; CD306; LAIR2; LAIR2/CD306 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of 20mM PB, 150mM NaCl, pH7.2.
• Sequence: Gln22-Pro152

• Species: Human
• Tag: C-Avi-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Biotinylated Recombinant Human Leukocyte-Associated Immunoglobulin-Like Receptor 2 is produced by our Mammalian expression system and the target gene encoding Gln22-Pro152 is expressed with a Avi, 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for LAIR2/CD306 recombinant protein

Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a secreted, 131 amino acid protein that contains one Ig-like C2 type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% amino acid identity across the signal sequence and extracellular domains; although one is secreted and one is membrane-bound, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. This suggests that LAIR-2 may compete with LAIR-1 for ligand binding. A 114 amino acid alternate splice form of LAIR-2 is truncated at the C terminus, but retains the entire Ig domain. The expression profile of these splice forms, and the presence of orthologs in other species, have not been reported.

Product Categories/Family for LAIR2/CD306 recombinant protein

immunology

NCBI and Uniprot Product Information

• NCBI GI #: 10947101
• NCBI GeneID: 3904
• NCBI Accession #: NP_002279.2
• NCBI GenBank Nucleotide #: NM_002288.5
• UniProt Accession #: Q6ISS4; Q6PEZ4
• Molecular Weight: 14,722 Da
• NCBI Official Full Name: leukocyte-associated immunoglobulin-like receptor 2 isoform a
• NCBI Official Synonym Full Names: leukocyte-associated immunoglobulin-like receptor 2
• NCBI Official Symbol: LAIR2
• NCBI Official Synonym Symbols: CD306
• NCBI Protein Information: leukocyte-associated immunoglobulin-like receptor 2; LAIR-2; leukocyte-associated Ig-like receptor 2; leukocyte-associated Ig-like receptor-2
• UniProt Protein Name: Leukocyte-associated immunoglobulin-like receptor 2
• UniProt Gene Name: LAIR2
• UniProt Synonym Gene Names: CD306; LAIR-2
• UniProt Entry Name: LAIR2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

Uniprot Description

LAIR-2: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: extracellular region