TRAILR4/TNFRSF10D/CD264 Recombinant Protein | TNFRSF10D recombinant protein

Recombinant Human TRAILR4/TNFRSF10D/CD264 Protein (C-Fc)

Cat. Num. AAA2557097

• Gene Names: TNFRSF10D; DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: TRAILR4/TNFRSF10D/CD264; Recombinant Human TRAILR4/TNFRSF10D/CD264 Protein (C-Fc); Tumor necrosis factor receptor superfamily member 10D; Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD264; TNFRSF10D; DCR2; TRAILR4; TRUNDD; TNFRSF10D recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Ala56-His211
• Sequence Length: 386

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for TNFRSF10D recombinant protein

Protein Construction: Recombinant Human TRAILR4 is produced by our mammalian expression system and the target gene encoding Ala56-His211 is expressed with a Fc tag at the C-terminus.

Background: Human TRAIL R4 is a type 1, TNF R family membrane protein, which is a receptor for TRAIL (APO2 ligand). TRAIL R4 contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. In the new TNF superfamily nomenclature, TRAIL R4 is referred to as TNFRSF10D. TRAIL R4 is unique among the TRAIL receptors in that its cytoplasmic domain contains a truncated consensus death domain motif. Binding of TRAIL R4 does not result in an apoptotic signal. Overexpression of TRAIL R4 can protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL mediated apoptosis. The human soluble TRAIL R4/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.

NCBI and Uniprot Product Information

• NCBI GI #: 22547108
• NCBI GeneID: 8793
• NCBI Accession #: NP_003831.2
• NCBI GenBank Nucleotide #: NP_003831.2
• UniProt Accession #: Q9UBN6
• Molecular Weight: Molecular Mass: 43.4kDa; Actual Protein Molecular Mass: 50-70kDa
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 10D
• NCBI Official Synonym Full Names: TNF receptor superfamily member 10d
• NCBI Official Symbol: TNFRSF10D
• NCBI Official Synonym Symbols: DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 10D
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 10D
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF10D
• UniProt Synonym Gene Names: DCR2; TRAILR4; TRUNDD; DcR2; TRAIL receptor 4; TRAIL-R4
• UniProt Entry Name: TR10D_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

TRAIL-R4: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: integral to membrane

Molecular Function: transmembrane receptor activity; TRAIL binding

Biological Process: apoptosis; signal transduction; negative regulation of apoptosis