Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Beta-adrenergic receptor kinase 2 (ADRBK2) Standard Curve.)
Rat Beta-Adrenergic Receptor Kinase 2 (ADRBK2) ELISA Kit | ADRBK2 elisa kit
Rat Beta-Adrenergic Receptor Kinase 2 (ADRBK2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Beta-adrenergic receptor kinase 2 (ADRBK2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Beta-adrenergic receptor kinase 2 (ADRBK2) Standard Curve.)
Background: The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. Beta adrenergic receptor kinase-2 (ARBK2, BARK-2, G-protein-coupled receptor kinase 3, GRK3) is an intracellular enzyme that phosphorylates G protein-coupled receptors. It was cloned from mice and rats in 1991. The human gene was cloned in 1993.
NCBI and Uniprot Product Information
NCBI Description
catalzyes phosphorylation of the beta-adrenergic receptor; may mediate desensitizaton of synaptic receptors; may regulate bone formation [RGD, Feb 2006]
Uniprot Description
GRK3: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.15; AGC group; GRK family; BARK subfamily
Cellular Component: membrane; axon; perinuclear region of cytoplasm; dendritic spine; synapse; dendritic shaft; Z disc; nucleus; cytosol; cilium
Molecular Function: protein serine/threonine kinase activity; G-protein coupled receptor kinase activity; beta-adrenergic receptor kinase activity; D1 dopamine receptor binding; ATP binding
Biological Process: intracellular protein transport; desensitization of G-protein coupled receptor protein signaling pathway; inositol phosphate metabolic process; negative regulation of G-protein coupled receptor protein signaling pathway; receptor internalization; multicellular organismal aging; rhodopsin metabolic process; positive regulation of protein amino acid phosphorylation; signal transduction; protein amino acid phosphorylation
Research Articles on ADRBK2
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Product Notes
The Rat ADRBK2 adrbk2 (Catalog #AAA9711978) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9711978 ELISA Kit recognizes Rat ADRBK2. It is sometimes possible for the material contained within the vial of "Beta-Adrenergic Receptor Kinase 2 (ADRBK2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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