Rabbit JMJD6 Polyclonal Antibody | anti-JMJD6 antibody

JMJD6 Polyclonal Antibody

Cat. Num. AAA2556228

• Gene Names: JMJD6; PSR; PTDSR; PTDSR1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: JMJD6; Polyclonal Antibody; JMJD6 Polyclonal Antibody; Apoptotic cell clearance receptor; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; JMJD 6; Jumonji domain containing 6; Jumonji domain-containing protein 6; KIAA0585; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR; PSR; PTDSR 1; PTDSR; PTDSR1; anti-JMJD6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
• Concentration: 0.76 mg/mL (varies by lot)
• Sequence Length: 372

• Applicable Applications for anti-JMJD6 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:1000-1:3000
• Immunogen: KLH conjugated synthetic peptide corresponding to Mouse JMJD6
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human colon cancer using JMJD6 Polyclonal Antibody at dilution of 1:1000.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human stomach cancer using JMJD6 Polyclonal Antibody at dilution of 1:1000.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded mouse kidney using JMJD6 Polyclonal Antibody at dilution of 1:1000.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded rat heart using JMJD6 Polyclonal Antibody at dilution of 1:1000.)

Related Product Information for anti-JMJD6 antibody

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-JMJD6 antibody

Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Developmental Biology; Immunology; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 125988395
• NCBI GeneID: 23210
• NCBI Accession #: NP_001074930.1
• NCBI GenBank Nucleotide #: NM_001081461.1
• UniProt Accession #: Q6NYC1; Q86VY0; Q8IUM5; Q9Y4E2; B3KMN8; B4DGX1
• Molecular Weight: 43,109 Da
• NCBI Official Full Name: bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 1
• NCBI Official Synonym Full Names: jumonji domain containing 6, arginine demethylase and lysine hydroxylase
• NCBI Official Symbol: JMJD6
• NCBI Official Synonym Symbols: PSR; PTDSR; PTDSR1
• NCBI Protein Information: bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
• UniProt Protein Name: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
• Protein Family: Bifunctional arginine demethylase and lysyl-hydroxylase
• UniProt Gene Name: JMJD6
• UniProt Synonym Gene Names: KIAA0585; PTDSR; Protein PTDSR

NCBI Description

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.