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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human colorectal cancer using KLK6 Polyclonal Antibody at dilution of 1:200)

Rabbit KLK6 Polyclonal Antibody | anti-KLK6 antibody

KLK6 Polyclonal Antibody

Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Immunofluorescence
Purity
Antigen Affinity Purification
Synonyms
KLK6; Polyclonal Antibody; KLK6 Polyclonal Antibody; Kallikrein related peptidase 6; Klk-8; Klk8; Kallikrein-6; KLK 6; MGC9355; mGK 1; mGK1; MSP; PRSS 18; PRSS 9; anti-KLK6 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purification
Concentration
0.3 mg/mL (varies by lot)
Applicable Applications for anti-KLK6 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
IHC 1:100-1:300; IF 1:100-1:200
Immunogen
Recombinant Rat Prostatic glandular kallikrein-6 protein
Conjugation
Unconjugated
Buffer
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colorectal cancer using KLK6 Polyclonal Antibody at dilution of 1:200)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human colorectal cancer using KLK6 Polyclonal Antibody at dilution of 1:200)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human breast using KLK6 Polyclonal Antibody at dilution of 1:200)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human breast using KLK6 Polyclonal Antibody at dilution of 1:200)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Rat kidney using KLK6 Polyclonal Antibody at dilution of 1:200)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Rat kidney using KLK6 Polyclonal Antibody at dilution of 1:200)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Mouse kidney using KLK6 Polyclonal Antibody at dilution of 1:200)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Mouse kidney using KLK6 Polyclonal Antibody at dilution of 1:200)

Immunofluorescence (IF)

(Immunofluorescence analysis of U-2OS cells using KLK6 Polyclonal Antibody at dilution of 1:100)

Immunofluorescence (IF) (Immunofluorescence analysis of U-2OS cells using KLK6 Polyclonal Antibody at dilution of 1:100)
Related Product Information for anti-KLK6 antibody
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.
Product Categories/Family for anti-KLK6 antibody

NCBI and Uniprot Product Information

UniProt Accession #
Protein Family

NCBI Description

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Uniprot Description

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338).

Research Articles on KLK6

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Product Notes

The KLK6 (Catalog #AAA2554128) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KLK6 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KLK6 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunofluorescence (IF). IHC 1:100-1:300; IF 1:100-1:200. Researchers should empirically determine the suitability of the KLK6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KLK6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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