KLK6 Protein Recombinant Protein | KLK6 recombinant protein

Recombinant Rat KLK6 Protein (His Tag)

Cat. Num. AAA2569437

• Gene Names: Klk1c8; rk8; KLK8; Klk6; rGK-8; Klk1b21
• Purity: >80% as determined by reducing SDS-PAGE
• Synonyms: KLK6 Protein; Recombinant Rat KLK6 Protein (His Tag); Bssp; hK 6; hK6; Kallikrein 6 precursor; Kallikrein related peptidase 6; Kallikrein-6; Kallikrein6; KLK 6; Klk7; KLK9; Klk29; Klk6; KLK6; MGC9355; mGK 1; mGK1; MSP; Neurosin; Protease M; Protease serine 18; Protease serine 9; PRSS 18; PRSS 9; PRSS18; PRSS9; Serine protease 18; Serine protease 9; SP 59; SP59; Tissue kallikrein; TK; Zyme; KLK6 recombinant protein

• Host: E Coli
• Purity/Purification: >80% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4
• Sequence: Ile25-Pro261

• Species: Rat
• Tag: N-His
• Protein Construction: A DNA sequence encoding the Rat KLK6 (P36374-1)(Ile25-Pro261) was expressed with a polyhistidine tag at the N-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for KLK6 recombinant protein

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 61556850
• NCBI GeneID: 292866
• NCBI Accession #: NP_001013085.1
• NCBI GenBank Nucleotide #: NM_001013067.2
• UniProt Accession #: P36374
• Molecular Weight: 29,013 Da
• NCBI Official Full Name: prostatic glandular kallikrein-6
• NCBI Official Synonym Full Names: kallikrein 1-related peptidase C8
• NCBI Official Symbol: Klk1c8
• NCBI Official Synonym Symbols: rk8; KLK8; Klk6; rGK-8; Klk1b21
• NCBI Protein Information: prostatic glandular kallikrein-6; kallikrein 6; P1 Kallikrein; serine protease; tissue kallikrein; glandular kallikrein-8; kallikrein 1-related peptidase b21
• UniProt Protein Name: Prostatic glandular kallikrein-6
• Protein Family: Kallikrein
• UniProt Gene Name: Klk6
• UniProt Synonym Gene Names: Klk-8; Klk8; rGK-8
• UniProt Entry Name: KLK6_RAT

Uniprot Description

Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activity: Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.