Ephrin-B1/EFNB1 Recombinant Protein | EFNB1 recombinant protein

Recombinant Mouse Ephrin-B1/EFNB1 Protein (C-Fc-6His)

Cat. Num. AAA2553488

• Gene Names: Efnb1; Epl2; EFL-3; Elk-L; Eplg2; Lerk2; Stra1; Cek5-L; LERK-2
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Ephrin-B1/EFNB1; Recombinant Mouse Ephrin-B1/EFNB1 Protein (C-Fc-6His); Ephrin-B1; EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; EFNB1; EFL3; EPLG2; LERK2; EFNB1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Lys30-Ser229
• Sequence Length: 345

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: C-Fc-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for EFNB1 recombinant protein

Mouse Ephrin-B1 is a single-pass type I membrane protein which belongs to the ephrin family. It contains an ephrin RBD (ephrin receptor-binding) domain, and expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Ephrin-B1 is cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. It binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 6753726
• NCBI GeneID: 13641
• NCBI Accession #: NP_034240.1
• NCBI GenBank Nucleotide #: NM_010110.5
• UniProt Accession #: P52795
• Molecular Weight: Molecular Mass: 49.8 kDa; Actual Protein Molecular Mass: 58-80 kDa
• NCBI Official Full Name: ephrin-B1
• NCBI Official Synonym Full Names: ephrin B1
• NCBI Official Symbol: Efnb1
• NCBI Official Synonym Symbols: Epl2; EFL-3; Elk-L; Eplg2; Lerk2; Stra1; Cek5-L; LERK-2
• NCBI Protein Information: ephrin-B1
• UniProt Protein Name: Ephrin-B1
• Protein Family: Ephrin
• UniProt Gene Name: Efnb1
• UniProt Synonym Gene Names: Epl2; Eplg2; Lerk2; Stra1; CEK5-L; ELK-L; LERK-2

NCBI Description

This gene encodes a membrane protein that acts as a ligand for Eph family receptors. Signalling occurs bidirectionally in both the cell containing the receptor and the cell expressing this protein. Activity of this protein is important in neuronal axon growth and other developmental processes. [provided by RefSeq, May 2015]

Uniprot Description

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.