Immunohistochemistry (IHC)
(Immunochemical staining of human MPDU1 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human MPDU1 Polyclonal Antibody | anti-MPDU1 antibody
Anti-MPDU1 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
MPDU1; Polyclonal Antibody; Anti-MPDU1 Antibody; Rabbit Polyclonal; MPDU1 Antibody; Rabbit PAb; Antigen Affinity Purified; mannose-P-dolichol utilization defect 1; Anti-CDGIF Antibody; Anti-HBEBP2BPA Antibody; Anti-Lec35 Antibody; Anti-My008 Antibody; Anti-PP3958 Antibody; Anti-PQLC5 Antibody; Anti-SL15 Antibody; anti-MPDU1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human MPDU1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-MPDU1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human MPDU1 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human MPDU1 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human MPDU1 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human MPDU1 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-MPDU1 antibody
Mannose-phosphate-dolichol utilization defect 1 (MPDU1) plays a role in the utilization of dolichol-phosphate-mannose (DPM). CDG-If is caused by a defect in the gene MPDU1, the human homolog of hamster Lec35, and is the first disorder to affect the use, rather than the biosynthesis, of donor substrates for lipid-linked oligosaccharides. This leads to the synthesis of incomplete and poorly transferred precursor oligosaccharides lacking both mannose and glucose residues. Kato III cells lacking MPDU1 have all the hallmarks of a glycosylation-deficient cell line, including altered sensitivity to lectins and the formation of truncated Lipid-linked Oligosaccharides (LLOs). Kato III cells and the MPDU1-rescued Kato IIIM cells provide a novel model to examine the consequences of defective LLO biosynthesis both in vitro and in vivo.
References
van Tol W, et al. (2019) A mutation in mannose-phosphate-dolichol utilization defect 1 reveals clinical symptoms of congenital disorders of glycosylation type i and dystroglycanopathy. JIMD Rep 50 (1): 31-39.Kranz C, et al. (2001) A mutation in the human mpdu1 gene causes congenital disorder of glycosylation type if (cdg-if). J Clin Invest 108 (11): 1613-1619.Bennett DC, et al. (2018) Mpdu1 regulates ceacam1 and cell adhesion in vitro and in vivo. Glycoconj J 35 (3): 265-274.
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Product Notes
The MPDU1 (Catalog #AAA8108649) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MPDU1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MPDU1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the MPDU1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MPDU1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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