Description: A DNA sequence encoding the ectodomain of human endothelin converting enzyme 2 isoform A (NP_055508.3) (Gly 199-Trp 883) was fused with a polyhistidine tag at the N-terminus.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Description
ECE2: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.71; Membrane protein, integral; Methyltransferase, protein arginine, predicted; Protease; Vesicle
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: cytoplasmic vesicle membrane
Molecular Function: metalloendopeptidase activity; protein binding
Biological Process: brain development; cardioblast differentiation; cell-cell signaling; heart development; peptide hormone processing