CD1D / R3G1 recombinant protein

Recombinant Human CD1D / R3G1 Protein (His tag)

Cat. Num. AAA2545967

• Gene Names: CD1D; R3; CD1A; R3G1
• Purity: > 88 % as determined by SDS-PAGE
• Synonyms: CD1D / R3G1; Recombinant Human CD1D / R3G1 Protein (His tag); CD1D; CD1A; MGC34622; R3; CD1D / R3G1 recombinant protein

• Host: Human Cells
• Purity/Purification: > 88 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 335

• Application Notes: The recombinant human CD1D consists of 293 amino acids and predicts a molecular mass of 33.3 kDa. As a result of glycosylation, rh CD1D migrates as an approximately 45-50 kDa band in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Glu 20
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CD1D / R3G1 recombinant protein

A DNA sequence encoding the extracellular domain of human CD1D (NP_001757.1) (Met 1-Ser 301) was expressed, with a C-terminal polyhistidine tag.

NCBI and Uniprot Product Information

• NCBI GI #: 4502649
• NCBI GeneID: 912
• NCBI Accession #: NP_001757.1
• NCBI GenBank Nucleotide #: NM_001766.3
• UniProt Accession #: P15813; Q5W0J3; Q9UMM3; Q9Y5M4; D3DVD5
• Molecular Weight: 37,717 Da
• NCBI Official Full Name: antigen-presenting glycoprotein CD1d isoform 1
• NCBI Official Synonym Full Names: CD1d molecule
• NCBI Official Symbol: CD1D
• NCBI Official Synonym Symbols: R3; CD1A; R3G1
• NCBI Protein Information: antigen-presenting glycoprotein CD1d
• UniProt Protein Name: Antigen-presenting glycoprotein CD1d
• UniProt Gene Name: CD1D

NCBI Description

This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Description

CD1D: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.

Protein type: Apoptosis; Cell surface; Lipid-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: cell surface; cytoplasm; integral to plasma membrane; plasma membrane

Molecular Function: beta-2-microglobulin binding; cell adhesion molecule binding; endogenous lipid antigen binding; exogenous lipid antigen binding; histone binding; lipid antigen binding; receptor activity

Biological Process: antigen processing and presentation, endogenous lipid antigen via MHC class Ib; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; detection of bacterium; heterotypic cell-cell adhesion; positive regulation of innate immune response; positive regulation of T cell proliferation; regulation of immune response; T cell selection