Rabbit MAP4K1 Polyclonal Antibody | anti-MAP4K1 antibody

MAP4K1 Polyclonal Antibody

Cat. Num. AAA2521667

• Gene Names: MAP4K1; HPK1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: MAP4K1; Polyclonal Antibody; MAP4K1 Polyclonal Antibody; HPK1; anti-MAP4K1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 821

• Applicable Applications for anti-MAP4K1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human MAP4K1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain tissue using MAP4K1 Polyclonal Antibody at dilution 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using MAP4K1 Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-MAP4K1 antibody

This gene belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily. It plays a role in the response to environmental stress and hematopoietic lineage decisions and growth regulation. Appears to act upstream of the JUN N-terminal pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 110611908
• NCBI GeneID: 11184
• NCBI Accession #: NP_001036065.1
• NCBI GenBank Nucleotide #: NM_001042600.2
• Molecular Weight: 90,425 Da
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase kinase 1 isoform 1
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase kinase 1
• NCBI Official Symbol: MAP4K1
• NCBI Official Synonym Symbols: HPK1
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase kinase 1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; hematopoietic progenitor kinase 1
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase kinase 1
• Protein Family: Mitogen-activated protein kinase kinase kinase kinase
• UniProt Gene Name: MAP4K1
• UniProt Synonym Gene Names: HPK1; MEK kinase kinase 1; MEKKK 1
• UniProt Entry Name: M4K1_HUMAN

Uniprot Description

HPK1: a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription.

Protein type: Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; KHS subfamily

Chromosomal Location of Human Ortholog: 19q13.1-q13.4

Cellular Component: membrane; cytoplasm

Molecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase kinase activity; ATP binding; protein kinase activity

Biological Process: cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; activation of MAPKKK activity; response to stress; protein amino acid phosphorylation; activation of JNK activity