Immunohistochemistry (IHC)
(Anti-PCSK1N / PROSAAS antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Goat PCSK1N / PROSAAS Polyclonal Antibody | anti-PCSK1N antibody
Goat Polyclonal to Human PCSK1N / PROSAAS
Usage: Peptide ELISA: antibody detection limit dilution 1:1000. Western blot: Preliminary experiments in Human Brain and Pancreas lysates gave no specific signal but low background (at antibody concentration up to 1 ug/ml).
Immunohistochemistry (IHC)
(Anti-PCSK1N / PROSAAS antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunohistochemistry (IHC)
(Anti-PCSK1N / PROSAAS antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]
Uniprot Description
PCSK1N: May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: extracellular space; trans-Golgi network; secretory granule
Molecular Function: serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; receptor binding
Biological Process: response to dietary excess; neuropeptide signaling pathway; peptide hormone processing; response to cold
Research Articles on PCSK1N
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Product Notes
The PCSK1N pcsk1n (Catalog #AAA248597) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat Polyclonal to Human PCSK1N / PROSAAS reacts with Gibbon, Chimpanzee, Human, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's PCSK1N / PROSAAS can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA). ELISA (1:1000), IHC-P (5 ug/ml) Usage: Peptide ELISA: antibody detection limit dilution 1:1000. Western blot: Preliminary experiments in Human Brain and Pancreas lysates gave no specific signal but low background (at antibody concentration up to 1 ug/ml). Researchers should empirically determine the suitability of the PCSK1N pcsk1n for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCSK1N / PROSAAS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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