Typical Standard Curve/Testing Data
Human ProSAAS/PCSK1N (granin-like neuroendocrine peptide) ELISA Kit | ProSAAS/PCSK1N elisa kit
Human ProSAAS/PCSK1N (granin-like neuroendocrine peptide)
Typical Standard Curve/Testing Data
Typical Standard Curve/Testing Data
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]
Uniprot Description
PCSK1N: May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: extracellular space; secretory granule; trans-Golgi network
Molecular Function: endopeptidase inhibitor activity; receptor binding; serine-type endopeptidase inhibitor activity
Biological Process: neuropeptide signaling pathway; peptide hormone processing; response to cold; response to dietary excess
Research Articles on ProSAAS/PCSK1N
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Product Notes
The Human ProSAAS/PCSK1N pcsk1n (Catalog #AAA766146) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA766146 ELISA Kit recognizes Human ProSAAS/PCSK1N. It is sometimes possible for the material contained within the vial of "ProSAAS/PCSK1N (granin-like neuroendocrine peptide), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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