Goat SNX16 Polyclonal Antibody | anti-SNX16 antibody

Goat Polyclonal to Human SNX16

Cat. Num. AAA246723

• Reactivity: Gibbon, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat; Predicted Reactivity: Bat, Bovine, Pig (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: SNX16; Polyclonal Antibody; Goat Polyclonal to Human SNX16; Anti-SNX16 Antibody (N-Terminus) IHC-plus; Sorting nexin 16; Sorting nexin-16; Human SNX16; anti-SNX16 antibody

• Host: Goat
• Reactivity: Gibbon, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat; Predicted Reactivity: Bat, Bovine, Pig (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human SNX16. This antibody is expected to recognise both isoform a (NP_071416.2; NP_690049.1) and isoform b (NP_690050.1).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 344

• Applicable Applications for anti-SNX16 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:64000), IHC-P (3.75 ug/ml), WB (1:64000, 0.05 - 0.2 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide ATPYVPVPMPIGN-C from the N-terminus of human SNX16 (NP_071416.2; NP_690049.1; NP_690050.1).
• Immunogen Type: Synthetic peptide
• Immunogen: SNX16 antibody was raised against synthetic peptide ATPYVPVPMPIGN-C from the N-terminus of human SNX16 (NP_071416.2; NP_690049.1; NP_690050.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Horse, Rabbit (100%); Bovine, Bat, Pig (92%); Opossum, Chicken, Platypus, Lizard (85%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-SNX16 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-SNX16 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-SNX16 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Western Blot (WB)

(Antibody (0.05 ug/ml) staining of Daudi lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

NCBI and Uniprot Product Information

• NCBI GI #: 23238244
• NCBI GeneID: 64089
• NCBI Accession #: NP_071416.2
• NCBI GenBank Nucleotide #: NM_022133.3
• UniProt Accession #: P57768; Q658L0; Q8N4U3; A8K4D8
• Molecular Weight: 35,566 Da
• NCBI Official Full Name: sorting nexin-16 isoform a
• NCBI Official Synonym Full Names: sorting nexin 16
• NCBI Official Symbol: SNX16
• NCBI Protein Information: sorting nexin-16
• UniProt Protein Name: Sorting nexin-16
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX16
• UniProt Entry Name: SNX16_HUMAN

NCBI Description

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The function of this protein has not been determined. This gene results in three transcript variants encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

SNX16: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: lysosome; late endosome membrane; early endosome membrane; early endosome; late endosome

Molecular Function: identical protein binding; phosphoinositide binding

Biological Process: protein targeting to lysosome; early endosome to late endosome transport; endosome to lysosome transport