Immunohistochemistry (IHC)
(Anti-RGS3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Mouse anti-Human RGS3 Monoclonal Antibody | anti-RGS3 antibody
Mouse Monoclonal [clone 1E8-C7] (IgG1,k) to Human RGS3
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using transfected cell line lysates and the recombinant protein used as the immunogen.
Immunohistochemistry (IHC)
(Anti-RGS3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunohistochemistry (IHC)
(Anti-RGS3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to RGS3 on HeLa cell. [antibody concentration 10 ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to RGS3 on HeLa cell. [antibody concentration 10 ug/ml].)
Western Blot (WB)
(Western blot of RGS3 expression in transfected 293T cell line by RGS3 monoclonal antibody clone 1E8-C7.)
Western Blot (WB)
(Western blot of RGS3 expression in transfected 293T cell line by RGS3 monoclonal antibody clone 1E8-C7.)
ELISA (EIA)
(Detection limit for recombinant GST tagged RGS3 is 0.3 ng/ml as a capture antibody.)
ELISA (EIA)
(Detection limit for recombinant GST tagged RGS3 is 0.3 ng/ml as a capture antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
Uniprot Description
RGS3: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, RGS; GAPs
Chromosomal Location of Human Ortholog: 9q32
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol
Molecular Function: GTPase activator activity
Biological Process: regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity; inactivation of MAPK activity
Research Articles on RGS3
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Product Notes
The RGS3 rgs3 (Catalog #AAA246368) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal [clone 1E8-C7] (IgG1,k) to Human RGS3 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RGS3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA). ELISA, IF (10 ug/ml), IHC-P (5 ug/ml), WB Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using transfected cell line lysates and the recombinant protein used as the immunogen. Researchers should empirically determine the suitability of the RGS3 rgs3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RGS3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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