Rabbit anti-Human TRPV2 Polyclonal Antibody | anti-TRPV2 antibody

TRPV2, NT (TRPV2, VRL, Transient receptor potential cation channel subfamily V member 2, Osm-9-like TRP channel 2, Vanilloid receptor-like protein 1) (AP)

Cat. Num. AAA6358891

• Gene Names: TRPV2; VRL; VRL1; VRL-1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TRPV2; Polyclonal Antibody; NT (TRPV2; VRL; Transient receptor potential cation channel subfamily V member 2; Osm-9-like TRP channel 2; Vanilloid receptor-like protein 1) (AP); Vanilloid receptor-like protein 1; anti-TRPV2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-TRPV2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TRPV2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the N-terminal region of human TRPV2.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TRPV2 Antibody (N-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the TRPV2 antibody detected the TRPV2 protein (arrow).)

Related Product Information for anti-TRPV2 antibody

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.

Product Categories/Family for anti-TRPV2 antibody

Antibodies; Receptors

References

Mercado, J., et al. J. Neurosci. 30(40):13338-13347(2010). Nabissi, M., et al. Carcinogenesis 31(5):794-803(2010). Monet, M., et al. Cancer Res. 70(3):1225-1235(2010). Liu, G., et al. Cancer Genet. Cytogenet. 197(1):54-59(2010). Saunders, C.I., et al. Biochim. Biophys. Acta 1792(10):1019-1026(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 20127551
• NCBI GeneID: 51393
• NCBI Accession #: NP_057197.2
• NCBI GenBank Nucleotide #: NM_016113.4
• UniProt Accession #: Q9Y5S1; Q9Y670; A6NML2; A8K0Z0
• Molecular Weight: 85,981 Da
• NCBI Official Full Name: transient receptor potential cation channel subfamily V member 2
• NCBI Official Synonym Full Names: transient receptor potential cation channel subfamily V member 2
• NCBI Official Symbol: TRPV2
• NCBI Official Synonym Symbols: VRL; VRL1; VRL-1
• NCBI Protein Information: transient receptor potential cation channel subfamily V member 2
• UniProt Protein Name: Transient receptor potential cation channel subfamily V member 2
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPV2
• UniProt Synonym Gene Names: VRL; TrpV2; OTRPC2; VRL-1

NCBI Description

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

Uniprot Description

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.