Rabbit GLP1R/GLP-1R/GLP-1 Receptor Polyclonal Antibody | anti-GLP1R antibody

Rabbit Polyclonal to Human GLP1R/GLP-1R/GLP-1 Receptor

Cat. Num. AAA244676

• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Hamster, Pig, Rabbit, Sheep (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GLP1R/GLP-1R/GLP-1 Receptor; Polyclonal Antibody; Rabbit Polyclonal to Human GLP1R/GLP-1R/GLP-1 Receptor; Anti-GLP1R/GLP-1R/GLP-1 Receptor Antibody (N-Terminus) IHC-plus; GLP1R; GLP-1-R; GLP-1 receptor; GLP-1R; GLP-I receptor; Glp1 receptor; Human GLP1R/GLP-1R/GLP-1 Receptor; anti-GLP1R antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Hamster, Pig, Rabbit, Sheep (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GLP1R. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 463

• Applicable Applications for anti-GLP1R antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3 - 4 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 16 amino acid peptide from N-terminal extracellular domain of human GLP1R. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Mouse, Rat, Sheep, Bovine, Hamster, Elephant, Rabbit, Pig (94%).
• Immunogen Type: Synthetic peptide
• Immunogen: GLP1R/GLP-1R/GLP-1 Receptor antibody was raised against synthetic 16 amino acid peptide from N-terminal extracellular domain of human GLP1R. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Mouse, Rat, Sheep, Bovine, Hamster, Elephant, Rabbit, Pig (94%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GLP-1 Receptor / GLP1R antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3-4 ug/ml.)

Immunohistochemistry (IHC)

(Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GLP1R antibody

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis.

Product Categories/Family for anti-GLP1R antibody

Family: GPCR; Subfamily: Glucagon

NCBI and Uniprot Product Information

• NCBI GI #: 166795283
• NCBI GeneID: 2740
• NCBI Accession #: NP_002053.3
• NCBI GenBank Nucleotide #: NM_002062.3
• UniProt Accession #: P43220; Q2M229; Q99669
• Molecular Weight: 53,026 Da
• NCBI Official Full Name: glucagon-like peptide 1 receptor
• NCBI Official Synonym Full Names: glucagon-like peptide 1 receptor
• NCBI Official Symbol: GLP1R
• NCBI Protein Information: glucagon-like peptide 1 receptor; GLP-1R; GLP-1-R; GLP-1 receptor
• UniProt Protein Name: Glucagon-like peptide 1 receptor
• Protein Family: Glucagon-like peptide 1 receptor
• UniProt Gene Name: GLP1R
• UniProt Synonym Gene Names: GLP-1 receptor; GLP-1-R; GLP-1R
• UniProt Entry Name: GLP1R_HUMAN

Uniprot Description

GLP1R: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: transmembrane receptor activity; glucagon receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cAMP-mediated signaling; learning and/or memory; adenylate cyclase activation; energy reserve metabolic process; response to stress; regulation of insulin secretion; regulation of heart contraction