Rabbit anti-Human Glucagon-like Peptide 1 Receptor Polyclonal Antibody | anti-GLP1R antibody

Glucagon-like Peptide 1 Receptor (GLP1R)

Cat. Num. AAA615485

• Gene Names: GLP1R; MGC138331
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography
• Synonyms: Glucagon-like Peptide 1 Receptor; Polyclonal Antibody; Glucagon-like Peptide 1 Receptor (GLP1R); Anti -Glucagon-like Peptide 1 Receptor (GLP1R); anti-GLP1R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Glucagon-like Peptide 1 Receptor.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.

• Applicable Applications for anti-GLP1R antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry (Paraffin/frozen): 10-20ug/ml
• Immunogen: Synthetic peptide [KLH conjugated] made to the N-terminal domain.
• Positive Control: Human pancreas
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Testing Data

(Human pancreas (Islets of Langerhans) using MBS615485.)

Related Product Information for anti-GLP1R antibody

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003). GLP1R has been reported in pancreas, brain, heart, kidney, lung, and stomach. ESTs have been isolated from kidney and skin libraries.

Product Categories/Family for anti-GLP1R antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 6850948
• NCBI GeneID: 2740
• UniProt Accession #: P43220; Q2M229; Q99669
• Molecular Weight: 53,026 Da
• NCBI Official Full Name: glucagon-like peptide 1 receptor
• NCBI Official Synonym Full Names: glucagon-like peptide 1 receptor
• NCBI Official Symbol: GLP1R
• NCBI Official Synonym Symbols: MGC138331
• NCBI Protein Information: glucagon-like peptide 1 receptor; GLP-1R; GLP-1-R; GLP-1 receptor; OTTHUMP00000016340
• UniProt Protein Name: Glucagon-like peptide 1 receptor
• Protein Family: Glucagon-like peptide 1 receptor
• UniProt Gene Name: GLP1R
• UniProt Entry Name: GLP1R_HUMAN

Uniprot Description

GLP1R: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 2; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: transmembrane receptor activity; glucagon receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cAMP-mediated signaling; learning and/or memory; adenylate cyclase activation; energy reserve metabolic process; response to stress; regulation of insulin secretion; regulation of heart contraction