Rabbit SNW1 / SKIP Polyclonal Antibody | anti-SNW1 antibody

Rabbit Polyclonal to Human SNW1 / SKIP

Cat. Num. AAA240328

• Gene Names: SNW1; Bx42; SKIP; Prp45; SKIIP; PRPF45; NCOA-62
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified
• Synonyms: SNW1 / SKIP; Polyclonal Antibody; Rabbit Polyclonal to Human SNW1 / SKIP; Anti-SNW1 / SKIP Antibody (C-Terminus) IHC-plus; SNW1; Bx42; Homolog of Drosophila BX42; Prp45; PRPF45; SKI interacting protein; SKIIP; SKIP; NCOA-62; Nuclear protein SkiP; Ski-interacting protein; SNW domain containing 1; Human SNW1; anti-SNW1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: 16 amino acid peptide from near the carboxy terminus of human SkiP
• Purity/Purification: Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 536

• Applicable Applications for anti-SNW1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB; Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human SNW1 / SKIP.
• Immunogen Type: Synthetic peptide
• Immunogen: SNW1 / SKIP antibody was raised against synthetic peptide from human SNW1 / SKIP.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-SNW1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-SNW1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of SkiP in mouse skeletal muscle tissue lysate with SkiP antibody at (A) 0.5 and (B) 1 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 6912676
• NCBI GeneID: 22938
• NCBI Accession #: NP_036377.1
• NCBI GenBank Nucleotide #: NM_012245.2
• UniProt Accession #: Q13573; Q13483; Q32N03; Q5D0D6; A8K8A9
• Molecular Weight: 61,494 Da
• NCBI Official Full Name: SNW domain-containing protein 1
• NCBI Official Synonym Full Names: SNW domain containing 1
• NCBI Official Symbol: SNW1
• NCBI Official Synonym Symbols: Bx42; SKIP; Prp45; SKIIP; PRPF45; NCOA-62
• NCBI Protein Information: SNW domain-containing protein 1; nuclear protein SkiP; SKI interacting protein; SKI-interacting protein; homolog of Drosophila BX42; nuclear receptor coactivator, 62-kD; nuclear receptor coactivator NCoA-62
• UniProt Protein Name: SNW domain-containing protein 1
• Protein Family: SNW domain-containing protein
• UniProt Gene Name: SNW1
• UniProt Synonym Gene Names: SKIIP; SKIP
• UniProt Entry Name: SNW1_HUMAN

NCBI Description

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. [provided by RefSeq, Jul 2008]

Uniprot Description

Skip: Involved in vitamin D-mediated transcription. Can function as a splicing factor in pre-mRNA splicing. Belongs to the SNW family.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Spliceosome

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; spliceosome; transcription elongation factor complex b; nuclear matrix; nucleus; chromatin

Molecular Function: protein binding; vitamin D receptor binding; retinoic acid receptor binding; transcription coactivator activity; SMAD binding; Notch binding; transcription corepressor activity; nuclear hormone receptor binding

Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; positive regulation of neurogenesis; Notch signaling pathway; viral reproduction; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; positive regulation of nuclear mRNA splicing, via spliceosome; regulation of transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transcription, DNA-dependent; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; regulation of retinoic acid receptor signaling pathway