Rabbit Nuclear Protein Skip Polyclonal Antibody | anti-SNW1 antibody

Nuclear Protein Skip (SNW1, BX42, MGC119379, NCOA-62, PRP45, PRPF45, SKIIP)

Cat. Num. AAA612312

• Gene Names: SNW1; Bx42; SKIP; Prp45; SKIIP; PRPF45; NCOA-62; MGC119379
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Synonyms: Nuclear Protein Skip; Polyclonal Antibody; Nuclear Protein Skip (SNW1; BX42; MGC119379; NCOA-62; PRP45; PRPF45; SKIIP); Anti -Nuclear Protein Skip (SNW1; anti-SNW1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes Human Nuclear Protein Skip (SNW1). Species Crossreactivity: Human, Mouse, Rat.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-SNW1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Immunohistochemistry: 5ug/ml
• Immunogen: Synthetic peptide, KLH-conjugated. Epitope: 16 amino acid peptide from near the carboxy terminus of human SkiP
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(SNW1 / SKIP (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cortex, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.)

Immunohistochemistry (IHC)

(SNW1 / SKIP (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human thymus, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.)

Product Categories/Family for anti-SNW1 antibody

Antibodies; Abs to Nuclear Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 1236986
• NCBI GeneID: 22938
• UniProt Accession #: Q13573; Q13483; Q32N03; Q5D0D6; A8K8A9; Q0D2M5; Q6I9S2; Q6P151; Q9ULA6
• Molecular Weight: 61,494 Da
• NCBI Official Full Name: nuclear protein Skip
• NCBI Official Synonym Full Names: SNW domain containing 1
• NCBI Official Symbol: SNW1
• NCBI Official Synonym Symbols: Bx42; SKIP; Prp45; SKIIP; PRPF45; NCOA-62; MGC119379
• NCBI Protein Information: SNW domain-containing protein 1; nuclear protein SkiP; SKI interacting protein; SKI-interacting protein; homolog of Drosophila BX42; nuclear receptor coactivator, 62-kD; nuclear receptor coactivator NCoA-62
• UniProt Protein Name: SNW domain-containing protein 1
• Protein Family: SNW domain-containing protein
• UniProt Gene Name: SNW1
• UniProt Synonym Gene Names: SKIIP; SKIP
• UniProt Entry Name: SNW1_HUMAN

NCBI Description

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. [provided by RefSeq]

Uniprot Description

Skip: Involved in vitamin D-mediated transcription. Can function as a splicing factor in pre-mRNA splicing. Belongs to the SNW family.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Spliceosome

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; spliceosome; transcription elongation factor complex b; nuclear matrix; chromatin; nucleus

Molecular Function: protein binding; vitamin D receptor binding; retinoic acid receptor binding; transcription coactivator activity; Notch binding; SMAD binding; transcription corepressor activity; nuclear hormone receptor binding

Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; positive regulation of neurogenesis; viral reproduction; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of histone H3-K4 methylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of nuclear mRNA splicing, via spliceosome; nuclear mRNA splicing, via spliceosome; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transcription, DNA-dependent; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; regulation of retinoic acid receptor signaling pathway