Glypican 2 Protein | GPC2 protein

Eukaryotic Glypican 2 (GPC2)

Cat. Num. AAA2122467

• Applications: SDS-Page, Western Blot
• Purity: >90%
• Synonyms: Glypican 2; Eukaryotic Glypican 2 (GPC2); Cerebroglycan; Glypican Proteoglycan 2; Cerebroglycan Proteoglycan; Secreted glypican-2; GPC2 protein

• Host: CHO Cell
• Purity/Purification: >90%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Val338~Thr562
• Sequence Length: 450

• Applicable Applications for GPC2 protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Eukaryotic expression
• Species: Human
• Tag: N-terminal His Tag
• Isoelectric Point: 9.7
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for GPC2 protein

Tumor immunity; Neuro science

NCBI and Uniprot Product Information

• NCBI GI #: 11138123
• NCBI GeneID: 57053
• NCBI Accession #: NP_065135.2
• NCBI GenBank Nucleotide #: NP_065135.2
• UniProt Accession #: Q9GZZ6
• Molecular Weight: Predicted Molecular Mass: 25.6kDa; Accurate Molecular Mass: 33kDa, 65kDa
• NCBI Official Full Name: neuronal acetylcholine receptor subunit alpha-10 isoform a
• NCBI Official Synonym Full Names: cholinergic receptor nicotinic alpha 10 subunit
• NCBI Official Symbol: CHRNA10
• NCBI Protein Information: neuronal acetylcholine receptor subunit alpha-10
• UniProt Protein Name: Neuronal acetylcholine receptor subunit alpha-10
• Protein Family: Glypican
• UniProt Gene Name: CHRNA10
• UniProt Synonym Gene Names: NACHRA10; NACHR alpha-10
• UniProt Entry Name: ACH10_HUMAN

Uniprot Description

nAChRA10: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 10/CHRNA10 sub-subfamily.

Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; membrane; axon; perikaryon; cell junction

Molecular Function: calcium channel activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding

Biological Process: elevation of cytosolic calcium ion concentration; inner ear morphogenesis; detection of mechanical stimulus involved in sensory perception of sound; regulation of cell proliferation; synaptic transmission, cholinergic