Activity Data
(Figure 1. Cell proliferation of A549 cells after stimulated with GREM1.)
Gremlin 1 (GREM1) Active Protein | GREM1 active protein
Active Gremlin 1 (GREM1)
Gene Names
Grem1; drm; Cktsf1b1
Applications
Cell Culture, Activity Assays
Purity
> 95%
Synonyms
Gremlin 1 (GREM1); Active Gremlin 1 (GREM1); PIG2; CKTSF1B1; DAND2; IHG-2; DRM; Increased in high glucose protein 2; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1; BMP antagonist 1; GREM1 active protein
Purity/Purification
> 95%
Form/Format
Freeze-Dried Powder; 100mMNaHCO3, 500mMNaCl, pH8.3, Containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Sequence Length
184
Applicable Applications for GREM1 active protein
Cell Culture, Activity Assays
Species
Rat
Tag
No-Tag
Isoelectric Point
9.6
Subcellular Location
Secreted
Reconstitution
Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Preparation and Storage
Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Activity Data
(Figure 1. Cell proliferation of A549 cells after stimulated with GREM1.)
Activity Data
(Figure 1. Cell proliferation of A549 cells after stimulated with GREM1.)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
gremlin-1
NCBI Official Synonym Full Names
gremlin 1, DAN family BMP antagonist
NCBI Official Symbol
Grem1
NCBI Official Synonym Symbols
drm; Cktsf1b1
NCBI Protein Information
gremlin-1
UniProt Protein Name
Gremlin-1
Protein Family
UniProt Gene Name
Grem1
UniProt Synonym Gene Names
Cktsf1b1; Drm
UniProt Entry Name
GREM1_RAT
NCBI Description
protein may play a role in cellular growth control, viability and differentiation; high expression levels may induce apoptosis [RGD, Feb 2006]
Uniprot Description
Function: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.2 PublicationsManual assertion based on experiment in:Ref.1
Research Articles on GREM1
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Product Notes
The GREM1 grem1 (Catalog #AAA2105167) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Gremlin 1 (GREM1) can be used in a range of immunoassay formats including, but not limited to, Cell Culture, Activity Assays. Researchers should empirically determine the suitability of the GREM1 grem1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Gremlin 1 (GREM1), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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