Growth Arrest Specific Protein 6 (GAS6) Recombinant Protein | GAS6 recombinant protein

Recombinant Growth Arrest Specific Protein 6 (GAS6)

Cat. Num. AAA2018705

• Gene Names: Gas6; Gas-6
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Growth Arrest Specific Protein 6 (GAS6); Recombinant Growth Arrest Specific Protein 6 (GAS6); GAS6 recombinant protein

• Host: E.coli
• Purity/Purification: > 90%
• Form/Format: 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.
• Concentration: Original Concentration: 50ug/mL (varies by lot)
• Sequence: ER ECVEEVCSKE EAREVFENDP ETEYFYPRYQ ECMRKYGRPE EKNPDFAKCV QNLPDQCTPN PCDKKGTHIC QDLMGNFFCV CTDGWGGRLC DKDVNECVQK NGGCSQVCHN KPGSFQCACHSGFSLASDGQ TCQDIDECTD SDTCGDARCK NLPGSYSCLC D

• Applicable Applications for GAS6 recombinant protein: Positive Control; Immunogen; SDS-PAGE; Western Blot (WB).
• Organism Species: Mus musculus (Mouse)
• Source: Prokaryotic expression
• Residues: Glu59~Asp221
• Tags: N-terminal His and GST Tag
• Subcellular Location: Secreted
• Traits: Freeze-dried powder
• Predicted isoelectric point: 5.4
• Usage: Reconstitute in ddH2O to a concentration of 0-0.5 mg/mL. Do not vortex.
• Preparation and Storage: Storage:; Avoid repeated freeze/thaw cycles.; Store at 2-8°C for one month. ; Aliquot and store at -80°C for 12 months.; ; Stability Test:; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 145301603
• NCBI GeneID: 14456
• NCBI Accession #: NP_062394.2
• NCBI GenBank Nucleotide #: NM_019521.2
• UniProt Accession #: Q61592; Q99K57
• Molecular Weight: Predicted Molecular Mass: 48.2kDa; Accurate Molecular Mass: 48kDa as determined by SDS-PAGE reducing conditions.
• NCBI Official Full Name: growth arrest-specific protein 6
• NCBI Official Synonym Full Names: growth arrest specific 6
• NCBI Official Symbol: Gas6
• NCBI Official Synonym Symbols: Gas-6
• NCBI Protein Information: growth arrest-specific protein 6; GAS 6; AXL receptor tyrosine kinase ligand
• UniProt Protein Name: Growth arrest-specific protein 6
• Protein Family: Growth arrest-specific protein
• UniProt Gene Name: Gas6
• UniProt Synonym Gene Names: GAS-6
• UniProt Entry Name: GAS6_MOUSE

Uniprot Description

Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Ref.3

Subunit structure: Heterodimer and heterotetramer with AXL.

Subcellular location: Secreted

By similarity.

Post-translational modification: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium

By similarity.

Miscellaneous: GAS6 deficient mice show protection against thrombosis, but no spontaneous bleeding.

Sequence similarities: Contains 4 EGF-like domains.Contains 1 Gla (gamma-carboxy-glutamate) domain.Contains 2 laminin G-like domains.