Western Blot (WB)
(The anti-MLK2 Pab is used in Western blot to detect MLK2 in transfected COS7 cell lysate. Data is kindly provided by Drs. M.K. Barthwal and A. Rana from Texas A&M University, Health Science Center (Temple, TX).)
Rabbit anti-Human MLK2 Polyclonal Antibody | anti-MAP3K10 antibody
MLK2 Antibody (C-term)
Western Blot (WB)
(The anti-MLK2 Pab is used in Western blot to detect MLK2 in transfected COS7 cell lysate. Data is kindly provided by Drs. M.K. Barthwal and A. Rana from Texas A&M University, Health Science Center (Temple, TX).)
Western Blot (WB)
(The anti-MLK2 Pab is used in Western blot to detect MLK2 in transfected COS7 cell lysate. Data is kindly provided by Drs. M.K. Barthwal and A. Rana from Texas A&M University, Health Science Center (Temple, TX).)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Katoh, M., et al., Oncogene 10(7):1447-1451 (1995).
Dorow, D.S., et al., Eur. J. Biochem. 213(2):701-710 (1993).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
Uniprot Description
MLK2: a TKL kinase of the MLK family. A dual leucine zipper kinase. Phosphorylates and activates JNK and SEK1. Interacts with PAK and NCK. May be involved in nerve growth factor-induced neuronal apoptosis.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; EC 2.7.11.25; Kinase, protein; TKL group; MLK family; MLK subfamily
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein homodimerization activity; JUN kinase kinase kinase activity; bHLH transcription factor binding; transcription corepressor activity; ATP binding; protein kinase activity
Biological Process: positive regulation of JNK activity; smoothened signaling pathway; positive regulation of apoptosis; apoptosis; negative regulation of transcription factor activity; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; positive regulation of JNK cascade; signal transduction; activation of JNK activity; peptidyl-serine phosphorylation; JNK cascade; negative regulation of transcription, DNA-dependent; activation of JNKK activity
Research Articles on MAP3K10
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Product Notes
The MAP3K10 map3k10 (Catalog #AAA9214317) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 628-659. The MLK2 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MLK2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the MAP3K10 map3k10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MLK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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