Mouse GAS6 ELISA Kit | GAS6 elisa kit

Mouse GAS6 ELISA Kit

Cat. Num. AAA824875

• Gene Names: Gas6; Gas-6
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: GAS6; Mouse GAS6 ELISA Kit; AXLLG; Growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand; GAS6 elisa kit

• Reactivity: Mouse
• Specificity: The Mouse Flt3 Ligand ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Mouse Flt3 Ligand proteins within the range of 31.2 pg/ml-2000 pg/ml.
• Sequence Length: 674

• Applicable Applications for GAS6 elisa kit: Sandwich ELISA (SE)
• Samples: Cell Culture Supernatants, Serum
• Sensitivity: 10 pg/ml.
• Preparation and Storage: Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for GAS6 elisa kit

Principle of the Assay: The MyBioSource' Mouse Flt3 Ligand ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Mouse Flt3 Ligand in Cell Culture Supernatants, Serum. This assay employs an antibody specific for Mouse Flt3 Ligand coated on a 96-well plate. Standards and samples are pipetted into the wells and Flt3 Ligand present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Mouse Flt3 Ligand antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of Flt3 Ligand bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm!!Background/Introduction: Fms-related tyrosine kinase 3 ligand (FLT3LG), also known as Flt-3ligand or FL, is a protein which in humans is encoded by the FLT3LG gene. It is mapped to 19q13.3. Flt-3ligand is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, Flt-3ligand stimulates the proliferation and differentiation of various blood cell progenitors. Besides that, Flt-3ligand can control the development of Dendritic cells (DCs) and is particularly important for plasmacytoid DCs and CD8-positive classical DCs and their CD103-positive tissue counterparts. Flt-3ligand also can enhance the response of stem and primitive progenitor cells to other growth factors to generate all myeloid lineages except erythroid cells.

NCBI and Uniprot Product Information

• NCBI GI #: 145301603
• NCBI GeneID: 14456
• NCBI Accession #: NP_062394.2
• NCBI GenBank Nucleotide #: NM_019521.2
• UniProt Accession #: Q61592; Q99K57
• Molecular Weight: 74,610 Da
• NCBI Official Full Name: growth arrest-specific protein 6
• NCBI Official Synonym Full Names: growth arrest specific 6
• NCBI Official Symbol: Gas6
• NCBI Official Synonym Symbols: Gas-6
• NCBI Protein Information: growth arrest-specific protein 6; GAS 6; AXL receptor tyrosine kinase ligand
• UniProt Protein Name: Growth arrest-specific protein 6
• Protein Family: Growth arrest-specific protein
• UniProt Gene Name: Gas6
• UniProt Synonym Gene Names: GAS-6
• UniProt Entry Name: GAS6_MOUSE

Uniprot Description

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.