Mouse SUR1 / SUR2B Monoclonal Antibody | anti-SUR1 / SUR2B antibody
SUR1 / SUR2B Monoclonal Antibody
Gene Names
Abcc9; Sur2
Applications
Immunoblot, Western Blot
Synonyms
SUR1 / SUR2B; Monoclonal Antibody; SUR1 / SUR2B Monoclonal Antibody; Anti-SUR1/SUR2B; anti-SUR1 / SUR2B antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1
Specificity
This antibody recognizes mouse and rat SUR1 and SUR2B.
Sequence Length
1545
Applicable Applications for anti-SUR1 / SUR2B antibody
Immunoblot (IB)
Application Notes
Immunoblotting: Use at 1-2ug/ml. A band of ~175kDa is detected. Smaller fragments, most likely due to cleavage products, are also detected.
Antigen
Fusion protein corresponding to aa 1503-1545 (VHTILTADLVIVMKRGNILEYDTPESLLA QEDGVFASFVRADM, cytoplasmic C-terminus) of rat SUR2B (accession no. Q63563-2).
Positive Control
Mouse brain lysate.
Dilution Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freezing and thawing.
Related Product Information for anti-SUR1 / SUR2B antibody
Sulfonylurea receptors (SUR) are membrane proteins that are molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the SUR is to sense intracellular levels of ATP and ADP and facilitate the opening or closing of its associated Kir6.x potassium channel, thus monitoring the energy balance within cells.
Product Categories/Family for anti-SUR1 / SUR2B antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
174,306 Da
NCBI Official Full Name
sulfonylurea receptor 2B
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 9
NCBI Official Symbol
Abcc9
NCBI Official Synonym Symbols
Sur2
NCBI Protein Information
ATP-binding cassette sub-family C member 9
UniProt Protein Name
ATP-binding cassette sub-family C member 9
UniProt Gene Name
Abcc9
UniProt Synonym Gene Names
Sur2
UniProt Entry Name
ABCC9_RAT
NCBI Description
ATP-sensitive potassium channel subunit that confers ATP sensitivity and acts as receptor for sulfonylurea; may play a role in mesangial cell contractility in response to calcium ion transients [RGD, Feb 2006]
Uniprot Description
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Research Articles on SUR1 / SUR2B
Similar Products
Product Notes
The SUR1 / SUR2B abcc9 (Catalog #AAA190656) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SUR1 / SUR2B can be used in a range of immunoassay formats including, but not limited to, Immunoblot (IB). Immunoblotting: Use at 1-2ug/ml. A band of ~175kDa is detected. Smaller fragments, most likely due to cleavage products, are also detected. Researchers should empirically determine the suitability of the SUR1 / SUR2B abcc9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SUR1 / SUR2B, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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