Mouse SAP102 Monoclonal Antibody | anti-SAP102 antibody

Anti-SAP102 Monoclonal

Cat. Num. AAA190540

• Gene Names: Dlg3; Dlgh3; SAP102; mKIAA1232
• Reactivity: Human, mouse, rat
• Applications: Immunoblot, Western Blot
• Synonyms: SAP102; Monoclonal Antibody; Anti-SAP102 Monoclonal; anti-SAP102 antibody

• Host: Mouse
• Reactivity: Human, mouse, rat
• Clonality: Monoclonal
• Isotype: lgG1
• Clone Number: S19-2
• Specificity: SAP102; This antibody recognizes human, mouse, and rat SAP102. It does not cross-react with PSD95, SAP97, or Chapsyn-110.
• Form/Format: 100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
• Sequence Positions: 1-120

• Applicable Applications for anti-SAP102 antibody: Immunoblot
• Application Notes: Immunoblotting: use at 1ug/ml. A band of 105kDa is detected. This is a recommended concentration. User should determine optimal concentrations for their application. Positive control: Rat brain lysate.
• Antigen: Fusion protein aa 1-120 of rat SAP102 (accession no. Q62936)
• Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.

Related Product Information for anti-SAP102 antibody

Synapse-associated protein (SAP) 102 is a member of the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology with the PSD95 family of proteins that facilitate ion channel clustering at synaptic terminals. SAP102 consists of three 90 amino acid PDZ domains at its amino terminus, a Src homology 3 domain, and a guanylate kinase domain. All three PDZ domains of SAP102 participate in binding to the NMDA receptor, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). SAP102 also interacts with synaptic ras-GTPase acativating protein synGAP through its PDZ domains.

NCBI and Uniprot Product Information

• NCBI GI #: 1507670
• NCBI GeneID: 53310
• UniProt Accession #: P70175; Q52KF7; Q80TH1
• Molecular Weight: 93,482 Da
• NCBI Official Full Name: SAP102
• NCBI Official Synonym Full Names: discs, large homolog 3 (Drosophila)
• NCBI Official Symbol: Dlg3
• NCBI Official Synonym Symbols: Dlgh3; SAP102; mKIAA1232
• NCBI Protein Information: disks large homolog 3; SAP-102; OTTMUSP00000017771; discs large homolog 3; synapse-associated protein 102
• UniProt Protein Name: Disks large homolog 3
• UniProt Gene Name: Dlg3
• UniProt Synonym Gene Names: Dlgh3
• UniProt Entry Name: DLG3_MOUSE

Uniprot Description

DLG3: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: postsynaptic membrane; extracellular space; growth cone; tight junction; cell soma; basolateral plasma membrane; cytoplasm; postsynaptic density; plasma membrane; synapse; intercellular junction; dendritic shaft

Molecular Function: protein C-terminus binding; protein domain specific binding; ionotropic glutamate receptor binding; guanylate kinase activity; protein binding; ubiquitin protein ligase binding; protein phosphatase binding; kinase binding; phosphatase binding; PDZ domain binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; synaptic transmission; nervous system development; embryonic development; establishment of planar polarity; receptor clustering; nucleotide phosphorylation