Disks large homolog 3 Recombinant Protein | Dlg3 recombinant protein

Recombinant Rat Disks large homolog 3

Cat. Num. AAA1380297

• Gene Names: Dlg3; Dlgh3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Disks large homolog 3; Recombinant Rat Disks large homolog 3; PSD-95/SAP90-related protein 1; Synapse-associated protein 102; SAP-102; SAP102; Dlg3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-849aa; Full Length
• Sequence: MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASSGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKNTPKLNGSGPSWWPECTCTNRDWYEQASPAPLLVNPEALEPSLSVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVTYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIFDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL
• Sequence Length: 849

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for Dlg3 recombinant protein

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

References

SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo.Mueller B.M., Kistner U., Kindler S., Chung W.J., Kuhlendahl S., Fenster S.D., Lau L.-F., Veh R.W., Huganir R.L., Gundelfinger E.D., Garner C.C.Neuron 17:255-265(1996) SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.Takeuchi M., Hata Y., Hirao K., Toyoda A., Irie M., Takai Y.J. Biol. Chem. 272:11943-11951(1997) SynGAP a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.Kim J.H., Liao D., Lau L.-F., Huganir R.L.Neuron 20:683-691(1998) A novel family of adhesion-like molecules that interacts with the NMDA receptor.Wang C.Y., Chang K., Petralia R.S., Wang Y.X., Seabold G.K., Wenthold R.J.J. Neurosci. 26:2174-2183(2006) Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.Lee H.W., Choi J., Shin H., Kim K., Yang J., Na M., Choi S.Y., Kang G.B., Eom S.H., Kim H., Kim E.J. Neurosci. 28:14546-14556(2008)

NCBI and Uniprot Product Information

• NCBI GI #: 13928878
• NCBI GeneID: 58948
• NCBI Accession #: NP_113827.1
• NCBI GenBank Nucleotide #: NM_031639.1
• UniProt Accession #: Q62936; P70547
• Molecular Weight: 120.5 kDa
• NCBI Official Full Name: disks large homolog 3
• NCBI Official Synonym Full Names: discs large homolog 3
• NCBI Official Symbol: Dlg3
• NCBI Official Synonym Symbols: Dlgh3
• NCBI Protein Information: disks large homolog 3
• UniProt Protein Name: Disks large homolog 3
• Protein Family: Disks large
• UniProt Gene Name: Dlg3
• UniProt Synonym Gene Names: Dlgh3; SAP-102; SAP102
• UniProt Entry Name: DLG3_RAT

NCBI Description

human homolog is a protein with guanylate kinase activity; involved in synaptogenesis and cell proliferation [RGD, Feb 2006]

Uniprot Description

DLG3: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: basolateral plasma membrane; cell soma; cytoplasm; dendritic shaft; extracellular space; growth cone; intercellular junction; ionotropic glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; tight junction

Molecular Function: guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein domain specific binding; protein phosphatase binding; ubiquitin protein ligase binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; establishment of planar polarity; GDP metabolic process; GMP metabolic process; nervous system development; receptor clustering; synaptic transmission