FCAR recombinant protein

Recombinant Human FCAR protein

Cat. Num. AAA1562812

• Gene Names: FCAR; CD89; FcalphaRI; CTB-61M7.2
• Purity: >90% as determined by SDS-PAGE
• Synonyms: FCAR; Recombinant Human FCAR protein; Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD89; FCAR recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human FCAR (Gln22-Asn227) was fused with GST tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for FCAR recombinant protein

FCAR, also called FcalphaRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcalphaRI associates with the FcR gamma signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcalphaRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcalphaRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

Product Categories/Family for FCAR recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 119860
• NCBI GeneID: 2204
• UniProt Accession #: P24071; Q13603; Q13604; Q15727; Q15728; Q1AJL7; Q1AJL8; Q1AJL9; Q53X38; Q53X39; Q92587; Q92588
• Molecular Weight: 28,343 Da
• NCBI Official Full Name: Immunoglobulin alpha Fc receptor
• NCBI Official Synonym Full Names: Fc fragment of IgA receptor
• NCBI Official Symbol: FCAR
• NCBI Official Synonym Symbols: CD89; FcalphaRI; CTB-61M7.2
• NCBI Protein Information: immunoglobulin alpha Fc receptor
• UniProt Protein Name: Immunoglobulin alpha Fc receptor
• Protein Family: Immunoglobulin alpha Fc receptor
• UniProt Gene Name: FCAR
• UniProt Synonym Gene Names: CD89; IgA Fc receptor

NCBI Description

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.