ZGPAT blocking peptide

ZGPAT Peptide

Cat. Num. AAA153119

• Gene Names: ZGPAT; ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847
• Applications: Blocking (BL)
• Synonyms: ZGPAT; ZGPAT Peptide; ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847; Zinc finger CCCH-type with G patch domain-containing protein; G patch domain-containing protein 6; zinc finger; CCCH-type with G patch domain; ZGPAT blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 531

• Applicable Applications for ZGPAT blocking peptide: Blocking (BL)
• Application Notes: ZGPAT peptide is used for blocking the activity of ZGPAT antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 15 amino acids near the carboxy terminus of human ZGPAT.
• Preparation and Storage: Store ZGPAT peptide at -20 degree C, stable for one year.

Western Blot (WB)

(Western blot analysis of ZGPAT in SK-N-SH cell lysate with ZGPAT antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 133925793
• NCBI GeneID: 84619
• NCBI Accession #: NP_115916
• NCBI GenBank Nucleotide #: NM_032527.4
• UniProt Accession #: Q8N5A5; Q4VXN9; Q5JWI9; Q5JWJ0; Q8NC55; Q8WUV4; Q96JI0; Q96JU4; Q9H401; E1P5K1
• Molecular Weight: 20,697 Da
• NCBI Official Full Name: zinc finger CCCH-type with G patch domain-containing protein isoform a
• NCBI Official Synonym Full Names: zinc finger, CCCH-type with G patch domain
• NCBI Official Symbol: ZGPAT
• NCBI Official Synonym Symbols: ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847
• NCBI Protein Information: zinc finger CCCH-type with G patch domain-containing protein; g patch domain-containing protein 6; zinc finger CCCH domain-containing protein 9; zinc finger and G patch domain-containing protein
• UniProt Protein Name: Zinc finger CCCH-type with G patch domain-containing protein
• UniProt Gene Name: ZGPAT
• UniProt Synonym Gene Names: GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9; ZIP
• UniProt Entry Name: ZGPAT_HUMAN

Uniprot Description

ZGPAT: Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; transcription factor activity

Biological Process: negative regulation of epidermal growth factor receptor activity; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent